研究单位：[1]Taizhou Hanzhong biomedical co. LTD[2]Anhui Provincial Hospital Hefei, Anhui, China, 230001[3]The Second Affiliated Hospital of Anhui Medical University Hefei, Anhui, China, 230601[4]Beijing ChaoYang Hospital, Capital Medical University Beijing, Beijing, China, 100020[5]Cancer Hospital, Chinese Academy of Medical Sciences Beijing, Beijing, China, 100021[6]Peking Union Medical College Hospital Beijing, Beijing, China, 100032[7]Beijing Friendship Hospital, Capital Medical University Beijing, Beijing, China, 100050[8]Peking University Third Hospital Beijing, Beijing, China, 100191[9]Peking University Internationale Hospital Beijing, Beijing, China, 102206[10]Chongqing University Cancer Hospital Chongqing, Chongqing, China, 400030[11]Fujian Cancer Hospital Xiamen, Fujian, China, 350000[12]Gansu Wuwei Tumor Hospital Wuwei, Gansu, China, 350000[13]Affiliated Cancer Hospital of Guangzhou Medical University Guangzhou, Guangdong, China, 510095[14]Zhongshan People's Hospital Guangzhou, Guangdong, China, 528403[15]Peking University Shenzhen Hospital Shenzhen, Guangdong, China, 518035[16]Cancer Hospital Chinese Academy of Medical Sciences, Shenzhen Center Shenzhen, Guangdong, China, 518117[17]Guangxi Medical University Cancer Hospital Naning, Guangxi, China, 530021[18]The First Affiliated Hospital, Sun Yat-sen University Guangzhou, Guangzhou, China, 510080[19]The Fourth Hospital of Hebei Medical University Shijiazhuang, Hebei, China, 050011河北医科大学第四医院[20]The First Hospital of Hebei Medical University Shijiazhuang, Hebei, China, 050051[21]Affiliated Hospital of Hebei University Shijiazhuang, Hebei, China, 071000[22]The affiliated Cancer Hospital of Harbin Medical University Harbin, Heilongjiang, China, 150081[23]Henan Cancer Hospital Zhengzhou, Henan, China, 450008[24]The First Affiliated Hospital of Zhengzhou University Zhengzhou, Henan, China, 450052[25]The First Affiliated Hospital of Henan Science&Technology University Zhengzhou, Henan, China, 471000[26]Henan Provincial People's Hospital Zhengzhou, Henan, China, 540003[27]The Second Xiangya Hospital of Cancer South University Changsha, Hunan, China, 410000[28]Xiangya Hospital, Central South University Changsha, Hunan, China, 410000[29]Hunan Cancer Hospital Changsha, Hunan, China, 410200[30]The Affiliated People's Hospital of Inner Mongolia Medical University Huhhot, Inner Mongolia, China, 010000[31]Changzhou Cancer Hospital Changzhou, Jiangsu, China, 213000[32]Jiangsu Provincial Hospital Nanjing, Jiangsu, China, 210000[33]Nanjing Drum Tower Hospital Nanjing, Jiangsu, China, 210009[34]Zhongda Hospital Southeast Universtiy Nanjing, Jiangsu, China, 210009[35]Nantong Tumor Hospital Nantong, Jiangsu, China, 226006[36]The Second Affiliated Hospital of Soochow University Suzhou, Jiangsu, China, 215000[37]Xuzhou Central Hospital Xuzhou, Jiangsu, China, 221009[38]Yangzhou FIrst People's Hospital Yangzhou, Jiangsu, China, 225000[39]The First Affiliated Hospital of Nanchang University Nanchang, Jiangxi, China, 330006[40]Jiangxi Cancer Hospital Nanchang, Jiangxi, China, 330029[41]Jilin Cancer Hospital Changchun, Jilin, China, 130000[42]The First Hospital of Jilin University Changchun, Jilin, China, 130000[43]The First Hospital of China Medical University Shenyang, Liaoning, China, 110001[44]Liaoning Cancer Hospital Shenyang, Liaoning, China, 110042[45]General Hospital of Ningxia Medical University Yinchuan, Ningxia, China, 750001[46]Shandong Provincial Hospital Jinan, Shandong, China, 250000[47]Shandong Cancer Hospital Jinan, Shandong, China, 250117[48]The Affiliated Hospital of Qingdao University Qingdao, Shandong, China, 266000[49]Yantai Yuhuangding Hospital Yantai, Shandong, China, 264000[50]Shanghai General Hospital Shanghai, Shanghai, China, 200000[51]Shanghai Sixth People's Hospital Shanghai, Shanghai, China, 200233[52]Shanxi Cancer Hospital Taiyuan, Shanxi, China, 030013[53]The First Affiliated Hospital of Xi'an Jiaotong University Xi'an, Shanxi, China, 710061[54]Sichuan Cancer Hospital Chengdu, Sichuan, China, 610041[55]Tianjin Medical University General Hospital Tianjin, Tianjin, China, 300052[56]Hubei Cancer Hospital Hubei, Wuhan, China, 430000[57]The First Affiliated Hospital of Xinjiang Medical University Urumqi, Xinjiang, China, 830000[58]Xinjiang Medical University Cancer Hospital Urumqi, Xinjiang, China, 830000[59]Yunnan Cancer Hospital Kunming, Yunnan, China, 650100[60]The First Affiliated Hospital, Zhejiang University School of Medicine Hangzhou, Zhejiang, China, 310003[61]Zhejiang Provincial People's Hospital Hangzhou, Zhejiang, China, 310014[62]Sir Run Run Shaw Hospital, Medical School of Zhejiang University Hangzhou, Zhejiang, China, 310016[63]Zhejiang Cancer Hospital Hangzhou, Zhejiang, China, 310022[64]The First Affiliated Hospital of Wenzhou Medical University Wenzhou, Zhejiang, China, 325000[65]Anhui Provincial Cancer Hospital Hefei, Anhui, China, 230000
研究目的：
This is a randomized, double-blinded, multicenter study to evaluate the efficacy and safety of HX008 injection combined with irinotecan versus placebo combined with irinotecan as second-line therapy in patients with adcanced gastric or gastroesophageal junction (GEJ) adenocarcinoma who have had tumor progression after first-line treatment with platinum and/or fluropyrimidine therapy.
