A Efficacy and Safety Study of Anlotinib Hydrochloride Capsule Combined With Chemotherapy Versus Placebo Combined With Chemotherapy as First-line Treatment in Subjects With Advanced Non-squamous Cell Non-small Cell Lung Cancer
研究单位：[1]Chia Tai Tianqing Pharmaceutical Group Co., Ltd.[2]Anhui Chest Hospital Hefei, Anhui, China, 230011[3]Yijishan Hospital of Wannan Medical College Wuhu, Anhui, China, 242400[4]Beijing Chest Hospital, Capital Medical University Beijing, Beijing, China, 100010[5]Peking University Third Hospital Beijing, Beijing, China, 100010[6]The Sixth Medical Center of Chinese PLA General Hospital Beijing, Beijing, China, 100010[7]Xuanwu Hospital of Capital Medical University Beijing, Beijing, China, 100010[8]Chinese Academy of Medical Sciences, Peking Union Medical College Hospital Beijing, Beijing, China, 100032[9]The First Affiliated Hospital of Chongqing Medical University Chongqing, Chongqing, China, 431338[10]The Second Affiliated Hospital of Chinese PLA Army Medical University Chongqing, Chongqing, China, 431338[11]Fujian Cancer Hospital Fuzhou, Fujian, China, 350014[12]The First Hospital of Lanzhou University Lanzhou, Gansu, China, 730000[13]Gansu Wuwei Tumor Hospital Wuwei, Gansu, China, 733000[14]The Fifth Affiliated Hospital of Sun Yat-sen University Guangzhou, Guangdong, China, 510010[15]The First Affiliated Hospital of Guangdong Pharmaceutical University Guangzhou, Guangdong, China, 510010[16]Sun Yat-sen Memorial Hospital, Sun Yat-sen University Guangzhou, Guangdong, China, 510289[17]Meizhou People's Hospital Meizhou, Guangdong, China, 514798[18]Guangxi Medical University Affiliated Tumor Hospital Nanning, Guangxi, China, 530021[19]The Fourth Hospital of Hebei Medical University Shijiazhuang, Hebei, China, 050051河北医科大学第四医院[20]Xingtai People's Hospital Xingtai, Hebei, China, 540000[21]Harbin Medical University Cancer Hospital Harbin, Heilongjiang, China, 150081[22]First Affiliated Hospital of Henan University of Science and Technology Luoyang, Henan, China, 471000[23]The First Affiliated Hospital of Xinxiang Medical College Xinxiang, Henan, China, 455001[24]Henan Cancer Hospital Zhengzhou, Henan, China, 475000[25]Huazhong University of Science Tongji Hospital, Tongji Medical College Wuhan, Hubei, China, 430010[26]Xiangya Hospital Central South University Changsha, Hunan, China, 410008[27]Hunan Cancer Hospital Changsha, Hunan, China, 425001[28]Changzhou Second People's Hospital Changzhou, Jiangsu, China, 213004[29]Lianyungang First People's Hospital Lianyungang, Jiangsu, China, 222001[30]Affiliated Hospital of Nantong University Nantong, Jiangsu, China, 226691[31]The Affiliated Hospital of Xuzhou Medical University Xuzhou, Jiangsu, China, 221003[32]Subei People's Hospital Yangzhou, Jiangsu, China, 211400[33]The First Affiliated Hospital of Nanchang University Nanchang, Jiangxi, China, 330006[34]The Second Hospital of Jilin University Changchun, Jilin, China, 130011[35]The Second Affiliated Hospital of Dalian Medical University Dalian, Liaoning, China, 116001[36]The First Affiliated Hospital of China Medical University Shenyang, Liaoning, China, 110001[37]Liaoning Cancer Hospital Shenyang, Liaoning, China, 110042[38]The Affiliated Hospital of Inner Mongolia Medical University Hohhot, Neimenggu, China, 010010[39]Ningxia Medical University General Hospital Yinchuan, Ningxia, China, 750001[40]Qilu Hospital of Shandong University Jinan, Shandong, China, 250012[41]Affiliated Hospital of Jining Medical University Jining, Shandong, China, 272000[42]Linyi Cancer Hospital Linyi, Shandong, China, 277739[43]Tengzhou Central People's Hospital Tengzhou, Shandong, China, 277500[44]Fudan University Cancer Hospital Shanghai, Shanghai, China, 200032[45]Shanghai Chest Hospital Shanghai, Shanghai, China[46]Linfen Central Hospital Linfen, Shanxi, China, 314000[47]The First Hospital of Shanxi Medical University Taiyuan, Shanxi, China, 300409[48]Tangdu Hospital, The Fourth Military Medical University of PLA Xi'an, Shanxi, China, 710038[49]First Affiliated Hospital of Xi'an Jiaotong University Xi'an, Shanxi, China, 721001[50]Dazhou Central Hospital Dazhou, Sichuan, China, 635000[51]Tianjin Chest Hospital Tianjin, Tianjin, China, 300010[52]Tianjin Medical University General Hospital Tianjin, Tianjin, China, 300011[53]Tianjin Cancer Hospital Tianjin, Tianjin, China, 300060[54]Affiliated Tumor Hospital of Xinjiang Medical University Urumqi, Xinjiang, China, 830011[55]Yunnan Cancer Hospital Kunming, Yunnan, China, 650011[56]Zhejiang Cancer Hospital Hangzhou, Zhejiang, China, 310002[57]The First Affiliated Hospital, College of Medicine, Zhejiang University Hangzhou, Zhejiang, China, 310003[58]The Second Affiliated Hospital of Zhejiang University School of Medicine Hangzhou, Zhejiang, China, 310009[59]Ruian People's Hospital Ruian, Zhejiang, China, 325000[60]The Second Affiliated Hospital of Anhui Medical University Hefei, Anhui, China, 230001
研究目的：
This is a randomized, double-blind, multicenter phase III clinical study to evaluate efficacy and safety of anlotinib hydrochloride capsule combined with chemotherapy versus placebo combined with chemotherapy as first-line treatment in subjects with advanced non-squamous cell non-small cell lung cancer.
