机构：[1]Department of Obstetrics and Gynecology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China, 河北医科大学第四医院妇科临床科室[2]Department of Molecular Biology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China医技科室分子生物学室河北医科大学第四医院
ObjectiveThis study aims to investigate the effect of polymorphisms of programmed cell death-ligand 1 (PD-L1) on the risk and patient's outcomes of epithelial ovarian cancer (EOC). MethodsTotally, 568 patients and 532 healthy women were included. Three polymorphisms in the PD-L1 gene, rs2297136, rs4143815 and rs4742098, were genotyped by the polymerase chain reaction/ligase detection reaction (PCR-LDR). Survival analysis was performed in 234 patients (received primary debulking surgery followed by platinum-based chemotherapy). ResultsPatients with the rs2297136 AG + GG genotypes had shorter progression-free survival (PFS) (hazard ratio (HR)=1.44, 95% CI=1.03-2.01) and overall survival (OS) (HR=1.55, 95% CI=1.06-2.27) than those with the AA genotype. Moreover, the mRNA and protein expression levels of PD-L1 in EOC tissues with the rs2297136 AG + GG genotypes were remarkably higher than those with the AA genotype (P=0.032 and P=0.047, respectively). Survival analysis showed that high expression of PD-L1 mRNA was remarkably associated with worse 10-year PFS (HR=1.55, 95% CI=1.28-1.88) and OS (HR=1.51, 95% CI=1.00-2.28) in EOC patients. ConclusionsThe rs2297136 may not only effectively influence the expression of PD-L1, but also is significantly associated with EOC patients' outcomes.
基金：
This work was supported by the Scientific Foundation of Hebei
Province [grant number: 182777171], and the Scientific Research
Fund of Hebei Provincial Health and Family Planning Commission
[grant number: 20200099], and the Natural Science Foundation of
Hebei Province [grant number: H2020206385].
第一作者机构：[1]Department of Obstetrics and Gynecology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China,
通讯作者：
推荐引用方式(GB/T 7714)：
Sun Haiyan,Li Yan,Si Wengang,et al.Genetic Variation of PD-L1 Gene Affects its Expression and Is Related to Clinical Outcome in Epithelial Ovarian Cancer[J].FRONTIERS IN ONCOLOGY.2022,12:doi:10.3389/fonc.2022.763134.
APA：
Sun, Haiyan,Li, Yan,Si, Wengang,Hua, Tian,Chen, Juan&Kang, Shan.(2022).Genetic Variation of PD-L1 Gene Affects its Expression and Is Related to Clinical Outcome in Epithelial Ovarian Cancer.FRONTIERS IN ONCOLOGY,12,
MLA：
Sun, Haiyan,et al."Genetic Variation of PD-L1 Gene Affects its Expression and Is Related to Clinical Outcome in Epithelial Ovarian Cancer".FRONTIERS IN ONCOLOGY 12.(2022)
