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A polymorphism at the miR-502 binding site in the 3 ' untranslated region of the SET8 gene is associated with the risk of epithelial ovarian cancer

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收录情况： ◇ SCIE

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机构： [1]Department of Gynaecology Ultrasound, The Fourth Hospital of Hebei Medical University, Shijiazhuang, P.R. China [2]Department of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, P.R. China [3]Department Molecular Biology, Hebei Cancer Institute, The Fourth Hospital of Hebei Medical University, Shijiazhuang, P.R. China [4]Department of Obstetrics and Gynaecology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, P.R. China

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关键词： MicroRNA SET8 EOC cancer risk

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MicroRNAs (miRNAs) bind to the 3' untranslated regions (UTRs) of messenger RNAs, where they interfere with the translation of genes that regulate cell differentiation, apoptosis, and tumorigenesis. SET8 reportedly methylates TP53 and regulates genomic stability. We analyzed a single nucleotide polymorphism (rs16917496) within the miR-502 mRNA seed region of the 3' UTR of SET8 in Chinese epithelial ovarian cancer (EOC) patients. The SET8 CC genotype was associated with a decreased risk of EOC in this case-control study. The analysis of genetic polymorphisms in miRNA binding sites may help identify subgroups of populations that are at high risk for EOC.

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出版当年[2012]版：

大类 | 4 区医学

小类 | 4 区遗传学 4 区肿瘤学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区遗传学 4 区肿瘤学

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出版当年[2012]版：

Q3 GENETICS & HEREDITY Q3 ONCOLOGY

最新[2023]版：

Q4 GENETICS & HEREDITY Q4 ONCOLOGY

影响因子： 1.4 最新[2023版] 1.7 最新五年平均 1.915 出版当年[2012版] 1.915 出版当年五年平均 0 出版前一年[2011版] 2.417 出版后一年[2013版]

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第一作者机构： [1]Department of Gynaecology Ultrasound, The Fourth Hospital of Hebei Medical University, Shijiazhuang, P.R. China

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相关文献

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