机构：[1]Departments of Respiratory Medicine,The Fourth Hospital of Hebei Medical University, Shijiazhuang, P.R. China临床科室呼吸内科河北医科大学第四医院[2]Departments of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, P.R. China河北医科大学第四医院
microRNAs (miRNAs) bind to the 3 untranslated regions (UTRs) of messenger RNAs, where they interfere with translation of genes that regulate cell differentiation, apoptosis and tumourigenesis. The histone methyltransferase SET8 has been reported to methylate TP53 and regulate genomic stability. We analysed a single nucleotide polymorphism (rs16917496) within the miR-502 miRNA seed region at the 3' UTR of SET8 in small-cell lung cancer (SCLC) patients. The SEM CC+CT genotype was identified to be independently associated with longer survival in SCLC patients by multivariate analysis (relative risk, 0.453; 95% CI 0.217-0.944; p=0.035). The analysis of genetic polymorphisms in miRNA binding sites may help to identify patient subgroups at high risk of poor outcome.
基金：
National Natural Science
Foundation of China, no. 30801384.
第一作者机构：[1]Departments of Respiratory Medicine,The Fourth Hospital of Hebei Medical University, Shijiazhuang, P.R. China
通讯作者：
通讯机构：[2]Departments of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, P.R. China[*1]Department of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical University, 12 Jiankang Road, Shijiazhuang 050011, P.R. China
推荐引用方式(GB/T 7714)：
Ding Cuimin,Li Ruijuan,Peng Jingcui,et al.A polymorphism at the miR-502 binding site in the 3 ' untranslated region of the SET8 gene is associated with the outcome of small-cell lung cancer[J].EXPERIMENTAL AND THERAPEUTIC MEDICINE.2012,3(4):689-692.doi:10.3892/etm.2012.469.
APA：
Ding, Cuimin,Li, Ruijuan,Peng, Jingcui,Li, Shengmian&Guo, Zhanjun.(2012).A polymorphism at the miR-502 binding site in the 3 ' untranslated region of the SET8 gene is associated with the outcome of small-cell lung cancer.EXPERIMENTAL AND THERAPEUTIC MEDICINE,3,(4)
MLA：
Ding, Cuimin,et al."A polymorphism at the miR-502 binding site in the 3 ' untranslated region of the SET8 gene is associated with the outcome of small-cell lung cancer".EXPERIMENTAL AND THERAPEUTIC MEDICINE 3..4(2012):689-692
