机构：[1]Departments of Respiratory Medicine,The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China临床科室呼吸内科河北医科大学第四医院[2]Departments of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China临床科室消化内科河北医科大学第四医院
Accumulation of single-nucleotide polymorphisms (SNPs) in the displacement loop (D-loop) of mitochondrial DNA (mtDNA) may be associated with disease outcome. Our team investigated the prediction power of D-loop SNPs in non-small cell lung cancer (NSCLC) outcome. In an overall multivariate analysis, allele 16390 was identified as an independent predictor for NSCLC outcome. The length of survival of patients with allele 16390A was significantly shorter than that of patients with allele 16390G (relative risk, 0.323; 95% CI, 0.109-0.951; p=0.040). The analysis of genetic polymorphisms in the mitochondrial D-loop can help identify NSCLC patient subgroups at a high risk for a poor disease outcome.
基金：
National Natural Science
Foundation of China (no. 30801384).
第一作者机构：[1]Departments of Respiratory Medicine,The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China
通讯作者：
通讯机构：[2]Departments of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China[*1]Department of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical University, 12 Jiankang Road, Shijiazhuang, Hebei 050011, P.R. China
推荐引用方式(GB/T 7714)：
Ding Cuimin,Li Ruijuan,Wang Ping,et al.Sequence polymorphisms of the mitochondrial displacement loop and outcome of non-small cell lung cancer[J].EXPERIMENTAL AND THERAPEUTIC MEDICINE.2012,3(5):861-864.doi:10.3892/etm.2012.490.
APA：
Ding, Cuimin,Li, Ruijuan,Wang, Ping,Fan, Haiyan&Guo, Zhanjun.(2012).Sequence polymorphisms of the mitochondrial displacement loop and outcome of non-small cell lung cancer.EXPERIMENTAL AND THERAPEUTIC MEDICINE,3,(5)
MLA：
Ding, Cuimin,et al."Sequence polymorphisms of the mitochondrial displacement loop and outcome of non-small cell lung cancer".EXPERIMENTAL AND THERAPEUTIC MEDICINE 3..5(2012):861-864
