机构：[1]Departments of Gastroenterology and Hepatology,The Fourth Hospital of Hebei Medical University河北医科大学第四医院[2]Departments of Gynaecology Ultrasound, The Fourth Hospital of Hebei Medical University河北医科大学第四医院[3]Hebei Key Lab of Laboratory Animal Science, Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China
The accumulation of single nucleotide polymorphisms (SNPs) in the displacement loop (D-loop) of mitochondria] DNA (mtDNA) has been associated with various types of cancer. The association of SNPs with cancer risk and disease outcome has been exhaustively studied. In this study, we investigated the association of age-at-onset and SNPs in the mitochondrial D-loop using a population-based series of hepatocellular carcinoma (HCC) patients. Haplogroup M (489C) and allele 235G were identified for their association with the late onset of HCC by the log-rank test. In an overall multivariate analysis, haplogroup M (489C) was identified as an independent predictive factor for the age-at-onset of HCC at borderline significant levels [relative risk, 1.736; 95% confidence interval (CI), 0.967-3.115; p=0.065]. Genetic polymorphisms in the D-loop are predictive markers for age-at-onset in HCC patients. Accordingly, the analysis of genetic polymorphisms in the mitochondrial D-loop may help to identify HCC patient subgroups at high risk of early onset of the disease.
基金：
National Natural Science Foundation of China (No. 30801384). The research was
supported in part by the Natural Science Foundation of Hebei Province (No. C2008000958).
第一作者机构：[1]Departments of Gastroenterology and Hepatology,The Fourth Hospital of Hebei Medical University
通讯作者：
通讯机构：[2]Departments of Gynaecology Ultrasound, The Fourth Hospital of Hebei Medical University[3]Hebei Key Lab of Laboratory Animal Science, Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China[*1]Department of Gynaecology Ultrasound, The Fourth Hospital of Hebei Medical University, 12 Jiankang Road, Shijiazhuang, Hebei 050011, P.R. China
推荐引用方式(GB/T 7714)：
Guo Zhanjun,Yang Hua,Wang Cuiju,et al.Mitochondrial DNA haplogroup M is associated with late onset of hepatocellular carcinoma[J].EXPERIMENTAL AND THERAPEUTIC MEDICINE.2012,3(3):499-502.doi:10.3892/etm.2011.434.
APA：
Guo, Zhanjun,Yang, Hua,Wang, Cuiju&Liu, Shufeng.(2012).Mitochondrial DNA haplogroup M is associated with late onset of hepatocellular carcinoma.EXPERIMENTAL AND THERAPEUTIC MEDICINE,3,(3)
MLA：
Guo, Zhanjun,et al."Mitochondrial DNA haplogroup M is associated with late onset of hepatocellular carcinoma".EXPERIMENTAL AND THERAPEUTIC MEDICINE 3..3(2012):499-502
