机构：[1]Departments of Gastroenterology and Hepatology,The Fourth Hospital of Hebei Medical University河北医科大学第四医院[2]Departments of Gynaecology Ultrasound, The Fourth Hospital of Hebei Medical University河北医科大学第四医院妇产超声科医技科室[3]Hebei Key Lab of Laboratory Animal Science, Hebei Medical University, Shijiazhuang 050011, P.R. China
The accumulation of single nucleotide polymorphisms (SNPs) in the displacement loop (D-loop) of mitochondrial DNA (mtDNA) has been described for various types of cancer, and their association with cancer risk and disease outcome has been extensively identified. In the present study, we investigated the association between age-at-onset and SNPs in the mitochondrial D-loop using a population-based series of esophageal squamous cell carcinoma (ESCC) patients. The SNP sites of nucleotides 16266 C/T were identified for their association with age-at-onset using the log-rank test. The age-at-onset of patients with the minor allele T genotype was significantly lower than that of patients with the C genotype at the 16266 site (p=0.036). Genetic polymorphisms in the D-loop are predictive markers for age-at-onset in ESCC patients. Accordingly, the analysis of genetic polymorphisms in the mitochondrial D-loop may help identify ESCC patient subgroups at high risk of early onset.
基金：
National Natural Science
Foundation of P.R. China No. 30801384. The research was
supported in part by the Natural Science Foundation of Hebei
Province No. C2008000958.
第一作者机构：[1]Departments of Gastroenterology and Hepatology,The Fourth Hospital of Hebei Medical University
共同第一作者：
通讯作者：
通讯机构：[2]Departments of Gynaecology Ultrasound, The Fourth Hospital of Hebei Medical University[3]Hebei Key Lab of Laboratory Animal Science, Hebei Medical University, Shijiazhuang 050011, P.R. China[*1]Department of Gynaecology Ultrasound, The Fourth Hospital of Hebei Medical University, 12 Jiankang Road, Shijiazhuang 050011, P.R. China
推荐引用方式(GB/T 7714)：
Guo Zhanjun,Yang Hua,Zhang Fengbin,et al.Single nucleotide polymorphisms in the mitochondrial displacement loop and age-at-onset of esophageal squamous cell carcinoma[J].ONCOLOGY LETTERS.2012,3(2):482-484.doi:10.3892/ol.2011.494.
APA：
Guo, Zhanjun,Yang, Hua,Zhang, Fengbin,Zhang, Ruixing&Wang, Cuiju.(2012).Single nucleotide polymorphisms in the mitochondrial displacement loop and age-at-onset of esophageal squamous cell carcinoma.ONCOLOGY LETTERS,3,(2)
MLA：
Guo, Zhanjun,et al."Single nucleotide polymorphisms in the mitochondrial displacement loop and age-at-onset of esophageal squamous cell carcinoma".ONCOLOGY LETTERS 3..2(2012):482-484
