The histone methyltransferase SET8 is regulated by microRNA-502 through the binding site in its 3 '-untranslated region, and the rs16917496 polymorphism at the miR-502-binding site in the SET8 gene has been implicated in a number of cancer types. The rs16917496 polymorphism including CC, CT and TT genotypes was analyzed in patients with colorectal cancer; the CC genotype was identified to be independently associated with longer post-operative survival times using multivariate analysis (relative risk, 2.406; 95% confidence interval, 1.017-5.691; P=0.046). In addition, decreased SET8 expression was associated with the SET8 CC genotype and longer survival times for patients with colorectal cancer. The results of the present study indicated that miR-502 mediates SET8 expression at least partly by altering the binding affinity between miR-502 and SET8 so as to modify the colorectal cancer outcome. The results indicate that SET8 may be a novel target for colorectal cancer therapy.
第一作者机构：[1]Bethune Int Peace Hosp, Dept Pathol, Shijiazhuang 050082, Hebei, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[4]Hebei Med Univ, Hosp 4, Dept Gynaecol Ultrasound, 12 Jiankang Rd, Shijiazhuang 050011, Hebei, Peoples R China[*1]Department of Gynaecology Ultrasound, The Fourth Hospital of Hebei Medical University, 12 Jiankang Road, Shijiazhuang, Hebei 050011, P.R. China
推荐引用方式(GB/T 7714)：
Liu Shuang,Dong Hailing,Wu Jianhua,et al.Association of an miR-502-binding site polymorphism in the 3 '-untranslated region of SET8 with colorectal cancer[J].ONCOLOGY LETTERS.2019,17(4):3960-3964.doi:10.3892/ol.2019.10026.
APA：
Liu, Shuang,Dong, Hailing,Wu, Jianhua&Wang, Cuiju.(2019).Association of an miR-502-binding site polymorphism in the 3 '-untranslated region of SET8 with colorectal cancer.ONCOLOGY LETTERS,17,(4)
MLA：
Liu, Shuang,et al."Association of an miR-502-binding site polymorphism in the 3 '-untranslated region of SET8 with colorectal cancer".ONCOLOGY LETTERS 17..4(2019):3960-3964
