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BUB1 Is Identified as a Potential Therapeutic Target for Pancreatic Cancer Treatment

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收录情况： ◇ SCIE ◇ SSCI

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机构： [1]Department of General Surgery, Shijiazhuang People’s Hospital, Shijiazhuang, China, [2]Department of Medical Oncology, The Fourth Hospital of Hebei Medical University, Hebei Tumor Hospital, Shijiazhuang, China, [3]Translational Medicine, YuceBio Technology Co., Ltd., Shenzhen, China, [4]Internal Medical, University of Occupational and Environmental Health, Fukuoka, Japan

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关键词： pancreatic cancer single-cell data dendritic cells ligand-receptor interactions CD74 Bub1 therapeutic targets bioinformatics analysis

摘要：

Pancreatic cancer is one of the most challenging cancer types in clinical treatment worldwide. This study aimed to understand the tumorigenesis mechanism and explore potential therapeutic targets for patients with pancreatic cancer. Single-cell data and expression profiles of pancreatic cancer samples and normal tissues from multiple databases were included. Comprehensive bioinformatics analyses were applied to clarify tumor microenvironment and identify key genes involved in cancer development. Immense difference of cell types was shown between tumor and normal samples. Four cell types (B cell_1, B cell_2, cancer cell_3, and CD1C+_B dendritic cell_3) were screened to be significantly associated with prognosis. Three ligand-receptor pairs, including CD74-MIF, CD74-COPA, and CD74-APP, greatly contributed to tumorigenesis. High expression of BUB1 (BUB1 Mitotic Checkpoint Serine/Threonine Kinase) was closely correlated with worse prognosis. CD1C+_B dendritic cell_3 played a key role in tumorigenesis and cancer progression possibly through CD74-MIF. BUB1 can serve as a prognostic biomarker and a therapeutic target for patients with pancreatic cancer. The study provided a novel insight into studying the molecular mechanism of pancreatic cancer development and proposed a potential strategy for exploiting new drugs.

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出版当年[2022]版：

大类 | 3 区医学

小类 | 3 区公共卫生、环境卫生与职业卫生

最新[2025]版：

大类 | 3 区医学

小类 | 3 区公共卫生、环境卫生与职业卫生

JCR分区：

出版当年[2022]版：

Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

最新[2023]版：

Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

影响因子： 3 最新[2023版] 3.6 最新五年平均 5.2 出版当年[2022版] 5.5 出版当年五年平均 6.461 出版前一年[2021版] 3 出版后一年[2023版]

第一作者：

第一作者机构： [1]Department of General Surgery, Shijiazhuang People’s Hospital, Shijiazhuang, China,

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通讯作者：

通讯机构： [2]Department of Medical Oncology, The Fourth Hospital of Hebei Medical University, Hebei Tumor Hospital, Shijiazhuang, China,

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