Circular RNA circWWC3 augments breast cancer progression through promoting M2 macrophage polarization and tumor immune escape via regulating the expression and secretion of IL-4
机构：[1]Tumor research Institute, The Fourth Hospital of Hebei Medical University,Shijiazhuang 050017, Hebei, People’s Republic of China河北医科大学第四医院河北省肿瘤研究所临床科室[2]Key Laboratoryfor Tumor diagnosis, Prevention and Therapy in Hebei Province, Shijiazhuang050017, Hebei, People’s Republic of China[3]Animal Center, TheFourth Hospital of Hebei Medical University, Shijiazhuang 050017, Hebei, People’sRepublic of China河北医科大学第四医院实验动物中心医技科室[4]Radiology Department, The Fourth Hospital of HebeiMedical University, Shijiazhuang 050017, Hebei, People’s Republic of China
Interaction between tumor cells and tumor microenvironment (TME) is critical to promote tumor progression and metastasis. As the most abundant immune cells in TME, macrophages can be polarized into M2-like tumor-associated macrophages (TAMs) which further promote tumor progression. However, to date, the molecular mechanisms of TAM polarization in TME are still largely unknown. In the present study, we revealed that circular RNA circWWC3 could up-regulate the expression and secretion of IL-4 in breast cancer cells. Enhanced secretion of IL-4 from breast cancer cells could augment the M2-like polarization of macrophages in TME, which further promotes the migration of breast cancer cells. In addition, increased secretion of IL-4 from breast cancer cells could induce the expression PD-L1 in M2 macrophages. Moreover, up-regulated IL-4 also enhanced the expression of PD-L1 in breast cancer cells, which further facilitates breast cancer immune evasion. Though analyzing the expression of circWWC3, IL-4, PD-L1, and CD163 in 140 cases of breast cancer tissues, we found that high expression of circWWC3 was associated with poor overall survival and disease-free survival of breast cancer patients. Breast cancer patients with circWWC3(high)/PD-L1(high) breast cancer cells and CD163(high) macrophages had a poorer overall survival and disease-free survival. Conclusively, circWWC3 might augment breast cancer progression through promoting M2 macrophage polarization and tumor immune escape via regulating the expression and secretion of IL-4. CircWWC3 might be a potential therapeutic target in breast cancer.
第一作者机构：[1]Tumor research Institute, The Fourth Hospital of Hebei Medical University,Shijiazhuang 050017, Hebei, People’s Republic of China[2]Key Laboratoryfor Tumor diagnosis, Prevention and Therapy in Hebei Province, Shijiazhuang050017, Hebei, People’s Republic of China
共同第一作者：
通讯作者：
通讯机构：[1]Tumor research Institute, The Fourth Hospital of Hebei Medical University,Shijiazhuang 050017, Hebei, People’s Republic of China[2]Key Laboratoryfor Tumor diagnosis, Prevention and Therapy in Hebei Province, Shijiazhuang050017, Hebei, People’s Republic of China
推荐引用方式(GB/T 7714)：
Zheng Yang,Ren Shuguang,Zhang Yu,et al.Circular RNA circWWC3 augments breast cancer progression through promoting M2 macrophage polarization and tumor immune escape via regulating the expression and secretion of IL-4[J].CANCER CELL INTERNATIONAL.2022,22(1):doi:10.1186/s12935-022-02686-9.
APA：
Zheng, Yang,Ren, Shuguang,Zhang, Yu,Liu, Sihua,Meng, Lingjiao...&Sang, Meixiang.(2022).Circular RNA circWWC3 augments breast cancer progression through promoting M2 macrophage polarization and tumor immune escape via regulating the expression and secretion of IL-4.CANCER CELL INTERNATIONAL,22,(1)
MLA：
Zheng, Yang,et al."Circular RNA circWWC3 augments breast cancer progression through promoting M2 macrophage polarization and tumor immune escape via regulating the expression and secretion of IL-4".CANCER CELL INTERNATIONAL 22..1(2022)
