机构：[1]Department of Immunology, School of Basic Medicine, Hebei Medical University, 361 Zhongshan East Rd., Shijiazhuang 050017, China[2]The First Hospital of Hebei Medical University, Shijiazhuang 050030, China[3]The Forth Hospital of Hebei Medical University, Shijiazhuang 050011, China河北医科大学第四医院[4]Cancer Research Center, Beijing Chest Hospital, Capital Medical University/Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China
As the most abundant internal mRNA modification in eukaryotic cells, N-6-methyladenosine (m(6)A) has emerged as an important regulator of gene expression and has a profound impact on cancer initiation and progression. mRNA m(6)A modification is regulated by m(6)A methyltransferases, demethylases and reader proteins to fine tune gene expression at the post-transcriptional level. The most well-studied m(6)A methyltransferase, METTL3, plays critical roles in regulating gene expression and affecting the outcome of various cancers. In this review, we discuss the multifaceted roles of METTL3 in regulating specific molecular signaling pathways in different types of cancers and the recent progress on how METTL3 impacts the tumor immune microenvironment. Finally, we discuss future directions and the potential for therapeutic targeting of METTL3 in cancer treatment.
基金：
Lung Cancer Project from Beijing Municipal Health Commission [2020-2022]
第一作者机构：[1]Department of Immunology, School of Basic Medicine, Hebei Medical University, 361 Zhongshan East Rd., Shijiazhuang 050017, China[2]The First Hospital of Hebei Medical University, Shijiazhuang 050030, China
通讯作者：
推荐引用方式(GB/T 7714)：
Hu Chenxi,Liu Jiacheng,Li Yue,et al.Multifaceted Roles of the N-6-Methyladenosine RNA Methyltransferase METTL3 in Cancer and Immune Microenvironment[J].BIOMOLECULES.2022,12(8):doi:10.3390/biom12081042.
APA：
Hu, Chenxi,Liu, Jiacheng,Li, Yue,Jiang, Wei,Ji, Ding...&Ma, Teng.(2022).Multifaceted Roles of the N-6-Methyladenosine RNA Methyltransferase METTL3 in Cancer and Immune Microenvironment.BIOMOLECULES,12,(8)
MLA：
Hu, Chenxi,et al."Multifaceted Roles of the N-6-Methyladenosine RNA Methyltransferase METTL3 in Cancer and Immune Microenvironment".BIOMOLECULES 12..8(2022)
