Background: In recent years, the incidence of serious complications in patients with advanced colorectal cancer has been progressively increasing, and the fatality rate of secondary bleeding is the highest, while most patients cannot undergo surgical intervention due to physical weakness, while interventional embolization therapy has attracted more and more attention of clinicians because of its advantages of small trauma and quick effect. Among them, multiple cases of secondary hemorrhage of different arteries are very rare. In this case, the changes of vital signs of patients were significantly stabilized after each interventional embolization therapy. Interventional embolization therapy can be used as one of the first choice for secondary hemorrhage. Case Description: Retrospectively analyzed the clinical data of a patient with advanced colorectal cancer who successively developed 7 times of secondary hemorrhage within 10 months. The two times of hemorrhage had different degrees of hemorrhagic shock, and five times showed unexplained progressive decrease in hemoglobin. The location of each hemorrhage and the arteries invaded by the tumor were different, and the embolization materials and treatment methods used each time were not the same. The effect of interventional embolization each time could effectively stop bleeding, and the patient greatly improved the quality of life with tumor survival. The patient prolonged the survival cycle for up to 16 months from the first secondary hemorrhage. Conclusions: For patients with advanced colorectal cancer complicated with secondary hemorrhage, interventional embolization can be used to control the disease and prolong the life cycle, which is one of the preferred treatment methods in clinical application.