机构：[1]Department of Hepatobiliary Surgery, The Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang,Hebei 050011临床科室肝胆外科河北医科大学第四医院[2]School of Basic Medicine, Hebei Medical University, Shijiazhuang, Hebei 050017, P.R. China
This study explored the correlation between semaphorin 4D (SEMA4D) and the prognosis and survival time of patients with melanoma combined with liver cancer. A total of 272 patients were recruited, and clinical and follow-up data were recorded. The expression levels of SEMA4D and SEMA3B were determined. Pearson's chi(2) test and Spearman's rank correlation coefficient were used to analyze the relationship between prognosis and the assessed parameters of melanoma patients. Univariate and multivariate Logistic regression and Cox proportional risk regression analyses were used for further analysis. Additionally, receiver operating characteristic curve and survival curves of subjects were plotted. The Pearson's chi(2) test showed that the prognosis of melanoma patients was significantly correlated with age, tumor grade, and decreased SEMA4D expression. Additionally, Spearman's correlation coefficient analysis showed that age, tumor grade, and SEMA4D expression were significantly correlated with prognosis. Univariate logistic regression analysis showed that age and tumor grade, and SEMA4D expression, were significantly correlated with prognosis. Older patients, a higher tumor grade, and lower SEMA4D expression were associated with a poorer prognosis. Multivariate logistic regression analysis showed that older patients had a poorer prognosis, and patients with lower SEMA4D expression levels had a significantly worse prognosis than patients with higher SEMA4D expression levels. Kaplan-Meier analysis showed that the survival time of older patients was lower than that of the younger patients. The survival times of patients with lower SEMA4D expression levels were significantly lower than that of patients with higher SEMA4D expression levels. Multivariate Cox regression analysis showed that the survival time of older patients was lower than that of younger patients. The survival time of melanoma patients with low SEMA4D expression was significantly lower than that of patients with higher SEMA4D expression. SEMA4D was significantly associated with melanoma, and lower SEMA4D expression was associated with a poorer survival prognosis in melanoma patients.
第一作者机构：[1]Department of Hepatobiliary Surgery, The Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang,Hebei 050011
通讯作者：
通讯机构：[1]Department of Hepatobiliary Surgery, The Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang,Hebei 050011[*1]Department of Hepatobiliary Surgery, The Fourth Affiliated Hospital of Hebei Medical University, 12 Chang'an District Health Road, Shijiazhuang, Hebei 050011, P.R. China
推荐引用方式(GB/T 7714)：
Liu Xiang,Zhang Chong,Yang Wu-Han,et al.Low expression of SEMA4D as a potential predictive molecular marker of poor survival in patients with melanoma combined with liver cancer[J].ONCOLOGY LETTERS.2023,25(4):doi:10.3892/ol.2023.13746.
APA：
Liu, Xiang,Zhang, Chong,Yang, Wu-Han,Li, Sheng-Chao,Wang, Rui-Feng...&Zhang, Zhi-Lei.(2023).Low expression of SEMA4D as a potential predictive molecular marker of poor survival in patients with melanoma combined with liver cancer.ONCOLOGY LETTERS,25,(4)
MLA：
Liu, Xiang,et al."Low expression of SEMA4D as a potential predictive molecular marker of poor survival in patients with melanoma combined with liver cancer".ONCOLOGY LETTERS 25..4(2023)
