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miR-141-3p accelerates ovarian cancer progression and promotes M2-like macrophage polarization by targeting the Keap1-Nrf2 pathway

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机构: [1]Hebei Med Univ, Hosp 4, Dept Gynecol, 12 Jiankang Rd, Shijiazhuang 050011, Hebei, Peoples R China [2]Hebei Med Univ, Hosp 4, Dept Reprod Med, Shijiazhuang 050011, Hebei, Peoples R China [3]Hebei Med Univ, Hosp 4, Dept Obstet, Shijiazhuang 050011, Hebei, Peoples R China
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关键词: ovarian cancer macrophage polarization miR-141-3p Keap1 Nrf2

摘要:
The miR-141-3p has been reported to participate in regulating autophagy and tumor-stroma interactions in ovarian cancer (OC). We aim to investigate whether miR-141-3p accelerates the progression of OC and its effect on macrophage 2 polarization by targeting the Kelch-like ECH-associated protein1-Nuclear factor E2-related factor2 (Keap1-Nrf2) pathway. SKOV3 and A2780 cells were transfected with miR-141-3p inhibitor and negative control to confirm the regulation of miR-141-3p on OC development. Moreover, the growth of tumors in xenograft nude mice treated by cells transfected with miR-141-3p inhibitor was established to further testify the role of miR-141-3p in OC. The expression of miR-141-3p was higher in OC tissue compared with non-cancerous tissue. Downregulation of miR-141-3p inhibited the proliferation, migration, and invasion of ovarian cells. Furthermore, miR-141-3p inhibition also suppressed M2-like macrophage polarization and in vivo OC progression. Inhibition of miR-141-3p significantly enhanced the expression of Keap1, the target gene of miR-141-3p, and thus downregulated Nrf2, while activation of Nrf2 reversed the reduction in M2 polarization by miR-141-3p inhibitor. Collectively, miR-141-3p contributes to tumor progression, migration, and M2 polarization of OC by activating the Keap1-Nrf2 pathway. Inhibition of miR-141-3p attenuates the malignant biological behavior of ovarian cells by inactivating the Keap1-Nrf2 pathway.

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出版当年[2023]版:
大类 | 4 区 医学
小类 | 4 区 医学:内科
最新[2025]版:
大类 | 4 区 医学
小类 | 4 区 医学:内科
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出版当年[2023]版:
Q2 MEDICINE, GENERAL & INTERNAL
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Q2 MEDICINE, GENERAL & INTERNAL

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第一作者机构: [2]Hebei Med Univ, Hosp 4, Dept Reprod Med, Shijiazhuang 050011, Hebei, Peoples R China
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通讯机构: [1]Hebei Med Univ, Hosp 4, Dept Gynecol, 12 Jiankang Rd, Shijiazhuang 050011, Hebei, Peoples R China
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