Nicaraven-Loaded Alginate Hydrogels Augment Bone Tissue Repair by Enhancing the Expression Level of Type Collagen Type II and TGF-ii Genes; An In Vitro an In Vivo Evaluation
In this research, a composite delivery system was developed by incorporating nicaraven-loaded chitosan nanoparticles into the matrix of alginate-based hydrogels. In vitro studies including scanning electron microscopy, cell viability assay, cytoprotection assay, cell migration assay, swelling assay, and drug release assay were performed to characterize the hydrogel system. In vivo study was performed in a rat model of calvarial bone defect. Histopathological examinations showed that the level of bone tissue repair was significantly higher in nicaraven-delivering hydrogels compared with other IP 203810920 On: Wed 17 May 2023 14:51:11 groups. Gene expression studies showed that he dveloped dlivery system nhanced the tissue expression levels Copyright: American Scientific Publishers collagen type II and TGF-f3 genes.
第一作者机构：[1]Cangzhou Hosp Integrated TCM WM, Dept Pediat Orthopaed, Hebei 061001, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Song Xiaolei,Yin Shuai,Zhao Feifei,et al.Nicaraven-Loaded Alginate Hydrogels Augment Bone Tissue Repair by Enhancing the Expression Level of Type Collagen Type II and TGF-ii Genes; An In Vitro an In Vivo Evaluation[J].JOURNAL OF BIOMEDICAL NANOTECHNOLOGY.2023,19(2):330-335.doi:10.1166/jbn.2023.3523.
APA：
Song, Xiaolei,Yin, Shuai,Zhao, Feifei,Zhang, Wenlu&Rohani, Saeed.(2023).Nicaraven-Loaded Alginate Hydrogels Augment Bone Tissue Repair by Enhancing the Expression Level of Type Collagen Type II and TGF-ii Genes; An In Vitro an In Vivo Evaluation.JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,19,(2)
MLA：
Song, Xiaolei,et al."Nicaraven-Loaded Alginate Hydrogels Augment Bone Tissue Repair by Enhancing the Expression Level of Type Collagen Type II and TGF-ii Genes; An In Vitro an In Vivo Evaluation".JOURNAL OF BIOMEDICAL NANOTECHNOLOGY 19..2(2023):330-335
