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Effects of 3021 meal replacement powder protect NAFLD via suppressing the ERS , oxidative stress and inflammatory responses

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机构： [1]Hebei Med Univ, Hosp 4, Shijiazhuang, Peoples R China [2]Shenzhen Anxintang Biotechnol Co Ltd, Shenzhen, Peoples R China [3]Xinchen Biotechnol Guandong Co Ltd, Dongguan, Peoples R China [4]Hebei Med Univ, Hosp 1, Hebei Prov Key Lab Nutr & Hlth, Shijiazhuang, Peoples R China [5]Hebei Med Univ, Hosp 3, Shijiazhuang, Peoples R China

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关键词： 3021 meal replacement powder miR-26a NAFLD Obesity ERS Oxidative stress Inflammation

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Objective: To explore the specific protective mechanism of 3021 meal replacement powder (MRP) against non-alcoholic fatty liver disease (NAFLD). Materials and Methods: C57BL/6J male mice were divided into four groups: control group, 3021 MRP group, model group and test group. The lipid accumulation and endoplasmic reticulum stress (ERS)-related proteins in hepatocytes of mice were detected by hematoxylin-eosin (HE) staining, oil red O staining and Western blotting. Results: The expressions of GRP78, GRP94, p-PERK and p-IRE1awere significantly inhibited in test group compared with those in model group. The protein expressions of p-NF-kappa B, p-JNK, IL-1 beta, IL-18 and NOX4 in test group were also significantly lower than those in model group. In vivo and in vitro experiments revealed that the body weight and lipid droplet content, and the expressions of ERS-related proteins (including BIP and XBP-1) in liver tissues all significantly declined in model group compared with those in 3021 MRP group. Conclusion: In conclusion, 3021 MRP can greatly reduce lipid accumulation by inhibiting ERS, oxidative stress and inflammatory response in NAFLD.

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出版当年[2023]版：

大类 | 3 区生物学

小类 | 3 区综合性期刊

最新[2025]版：

大类 | 3 区生物学

小类 | 3 区综合性期刊

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出版当年[2023]版：

Q2 MULTIDISCIPLINARY SCIENCES

最新[2024]版：

Q2 MULTIDISCIPLINARY SCIENCES

影响因子： 2.4 最新[2024版] 2.7 最新五年平均 2.3 出版当年[2023版] 2.8 出版当年五年平均 2.7 出版前一年[2022版] 2.4 出版后一年[2024版]

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第一作者机构： [1]Hebei Med Univ, Hosp 4, Shijiazhuang, Peoples R China

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