The ketogenic diet (KD) has made a breakthrough in the treatment of glioma and has become a research hotspot because of its unique dietary structure, particularly as an auxiliary strategy for anti-tumor. This article reviews the application and mechanism of KD combined with other anti-tumor methods, such as chemoradiotherapy, immunotherapy, molecularly targeted drugs, anti-angiogenic drugs, glucose-targeted drugs, hyperbaric oxygen, ketone bodies, and intestinal flora, aiming to provide a theoretical basis for the clinical application of KD.