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Development of a clinical prognostic model for primary plasma cell leukemia patients treated with novel agents: a multicenter retrospective cohort study

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机构： [1]Department of Hematology, Beijing Chao-Yang Hospital, Capital Medical University, 8 Gongren Tiyuchang Nanlu, Chaoyang District, Beijing, China [2]Department of Hematology, Second Hospital of Shanxi Medical University, Taiyuan, China [3]Department of Hematology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China [4]Department of Hematology, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, China [5]Department of Oncology, The First Hospital of Jilin University, Changchun, China [6]Department of Hematology, The First Affiliated Hospital, Harbin Medical University, Harbin, China [7]Department of Hematology, Affiliated Hospital of Chengde Medical University, Chengde, China [8]Department of Hematology, Chifeng Municipal Hospital, Chifeng, China [9]Department of Hematology, Linyi Central Hospital, Linyi, China [10]Department of Hematology, Shanxi Provincial Cancer Hospital, Taiyuan, China [11]Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China [12]Department of Hematology, Shanxi Bethune Hospital of Shanxi Medical University, Taiyuan, China [13]Department of Hematology, The Second Hospital of Hebei Medical University, Shijiazhuang, China [14]Department of Hematology, The Second Affiliated Hospital of Nanchang University, Nanchang, China [15]Department of Hematology, Affiliated Hospital of Nantong University, Nantong, China [16]Department of Hematology, Hematology Research Center of Yunnan Province, The First Affiliated Hospital of Kunming Medical University, Kunming, China

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关键词： Plasma cell leukemia Nomogram Primary plasma cell leukemia Prognostic model

摘要：

The prognosis of primary plasma cell leukemia (pPCL) is poor, and the relevant prognostic factors are incompletely understood. We aimed to explore the prognostic factors and develop a validated prognostic prediction model for pPCL patients in the new era. This multicenter retrospective study was conducted across 16 hospitals in China. Cox proportional hazards regression analysis was used to develop a prediction model. The predictive performance of the model was assessed using multiple metrics. Internal validation was conducted using bootstrap resampling. A total of 102 pPCL patients were included in this study, and 57 (55.9%) were male. The 12-month, 24-month, and 36-month OS rates for pPCL patients were 75.4%, 58.3%, and 47.6%, respectively. An overall survival prognostic nomogram for pPCL patients was established by integrating independent prognostic factors, including age, B2MG, and del17p. The nomogram exhibited good performance, with a C-index of 0.720 (95% CI 0.642-0.797) and an AUC of 0.653. Bootstrap validation yielded a C-index of 0.721 (95% CI 0.629-0.787) and an AUC of 0.653 (95% CI 0.546-0.759), indicating a relatively good fit of the calibration curve. A nomogram incorporating age, B2MG grade, and del17p were developed and validated to accurately and consistently predict the prognosis of pPCL patients.© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

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出版当年[2025]版：

大类 | 3 区医学

小类 | 3 区血液学

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大类 | 3 区医学

小类 | 3 区血液学

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出版当年[2024]版：

无

最新[2023]版：

Q2 HEMATOLOGY

影响因子： 3 最新[2023版] 3.1 最新五年平均 3 出版当年[2024版] 3.1 出版当年五年平均 3 出版前一年[2023版]

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第一作者机构： [1]Department of Hematology, Beijing Chao-Yang Hospital, Capital Medical University, 8 Gongren Tiyuchang Nanlu, Chaoyang District, Beijing, China

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Development of a clinical prognostic model for primary plasma cell leukemia patients treated with novel agents: a multicenter retrospective cohort study

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