This study investigated the impact of Human Papillomavirus (HPV) on inflammation and growth in oral epithelial cells, with a focus on the role of Interleukin-37 (IL37). Oral epithelial cells, including HOEC and HSC-3 cells, were employed in the research. The results revealed that HPV significantly induced inflammation in both types of oral epithelial cells, concurrently promoting cell growth and inhibiting apoptosis. IL37, a cytokine, was found to mitigate HPV-induced inflammation in oral epithelial cells. Moreover, IL37 counteracted HPV's effects on apoptosis and cell viability in oral epithelial cells. The study also identified a reduction in autophagy in HPV-infected oral epithelial cells, a phenomenon alleviated by IL37. Furthermore, chemical inhibition of autophagy was observed to attenuate HPV-induced inflammation and growth in oral epithelial cells. These findings contribute valuable insights into the pathogenesis of inflammation in oral epithelial cells associated with HPV and oral cancers, offering potential avenues for novel therapeutic strategies.
基金：
Medical Science Research Project of Hebei Provincial Healthcare Commission [20240897]
第一作者机构：[1]Second Hosp Shijiazhuang, Dept Stomatol, Shijiazhuang 050000, Hebei, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[5]Hebei Med Univ, Hosp 4, Dept Endoscopy, 12 Hlth Rd, TEL, Shijiazhuang 050011, Hebei, Peoples R China
推荐引用方式(GB/T 7714)：
Shi Yahong,Wang Wenjing,Bai Yunfang,et al.IL-37 attenuated HPV induced inflammation and growth of oral epithelial cells via regulating autophagy[J].HELIYON.2024,10(15):doi:10.1016/j.heliyon.2024.e35131.
APA：
Shi, Yahong,Wang, Wenjing,Bai, Yunfang,Liu, Xiaoying,Wu, Liwei&Liu, Ning.(2024).IL-37 attenuated HPV induced inflammation and growth of oral epithelial cells via regulating autophagy.HELIYON,10,(15)
MLA：
Shi, Yahong,et al."IL-37 attenuated HPV induced inflammation and growth of oral epithelial cells via regulating autophagy".HELIYON 10..15(2024)
