Objectives This study aimed to evaluate the feasibility and accuracy of non-electrocardiogram (ECG)-triggered chest low-dose computed tomography (LDCT) with a kV-independent reconstruction algorithm in assessing coronary artery calcification (CAC) degree and cardiovascular disease risk in patients receiving maintenance hemodialysis (MHD). Methods In total, 181 patients receiving MHD who needed chest CT and coronary artery calcium score (CACS) scannings sequentially underwent non-ECG-triggered, automated tube voltage selection, high-pitch chest LDCT with a kV-independent reconstruction algorithm and ECG-triggered standard CACS scannings. Then, the image quality, radiation doses, Agatston scores (ASs), and cardiac risk classifications of the two scans were compared. Results Of the 181 patients, 89, 83, and 9 were scanned at 100, 110, and 120 kV, respectively. Excluding those scanned at 120 kV, 172 patients were enrolled. Although the ASs of non-ECG-triggered LDCT were lower than those of the standard CACS, the agreement and correlation of ASs of the two scans were excellent, and both intraclass correlation coefficients (ICCs) and Pearson's correlation coefficients were > 0.96. Cardiac risk classifications did not significantly differ between the non-ECG-triggered LDCT and standard CACS (chi(2) = 3.933, P = 0.269), and the agreement was excellent (weighted kappa value = 0.936; 95% confidence interval (CI): 0.903-0.970). The effective radiation doses of standard CACS and non-ECG-triggered chest LDCT scannings were 1.34 +/- 0.74 and 1.04 +/- 0.35 mSv, respectively. Conclusions The non-ECG-triggered, automated tube voltage selection, high-pitch chest LDCT protocol with a kV-independent reconstruction algorithm can obtain chest scans and ASs simultaneously and significantly reduce patients' radiation exposure.