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Chronic intermittent hypobaric hypoxia prevents pulmonary arterial hypertension through maintaining eNOS homeostasis

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收录情况： ◇ SCIE

作者：
Li Hai-Shuang[1] * ; Liu Hui-Jie[1] ; Zhang Yu[1] ; Zhang Jing[1] ; Yan Han-Yu[1] ; Yuan Wei-Cheng[1] ; Wang Sen[1] ; Yu Shuo[1] ; Yang Sheng-Qiang[1] ; Sun Meng-Wei[1] ; Qi Can-Yang[1] ; Miao Sui-Bing[3] ; Zhang Li-Ping[1] ; Guo Hui[4] ; Zhang Yi[1] ; Ma Hui-Jie[1,2,5] ; Guan Yue[1,2] ;
机构： [1]Department of Physiology, Hebei Medical University, Shijiazhuang, 050017, China [2]Hebei Key Laboratory of Neurophysiology, Shijiazhuang, 050017, China [3]Key Laboratory of Maternal and Fetal Medicine of Hebei Province, The Fourth Hospital of Shijiazhuang Affiliated to Hebei Medical University, Shijiazhuang, 050017, China [4]Department of Gynaecology and Obstetrics, Fourth Hospital of Hebei Medical University, Shijiazhuang, 050017, China [5]The Key Laboratory of Neural and Vascular Biology, Ministry of Education, Shijiazhuang, 050017, China
出处：
DOI： 10.1016/j.abb.2025.110340
ISSN：

关键词： Chronic intermittent hypobaric hypoxia Pulmonary artery hypertension Nitric oxide synthase hyperactivation Calmodulin Caveolin-1

摘要：
Pulmonary arterial hypertension (PAH) is a pathological condition in which pulmonary artery pressure is elevated which causes patients to die of right heart failure. Chronic intermittent hypobaric hypoxia (CIHH) represents a novel method of intermittently exposing subjects to a simulated plateau hypobaric hypoxia environment. This study investigates the potential preventive and protective effects of CIHH on PAH.Male Sprague-Dawley rats were randomly divided into four groups: control group (Con), chronic intermittent hypobaric hypoxia group (CIHH), pulmonary arterial hypertension group (PAH), chronic intermittent hypobaric hypoxia + pulmonary arterial hypertension group (CIHH + PAH). To evaluate the effects of CIHH on PAH, a range of techniques was employed, including pulmonary hemodynamics, vascular reactivity assay, Western blot, RNA sequencing, HE staining and co-immunoprecipitation.CIHH was demonstrated to reduce pulmonary artery constriction and enhance relaxation, reducing the mean pulmonary artery pressure in PAH rats. This is achieved through attenuating the CaM/eNOS (Calmodulin,CaM)protein interaction and increasing the CaV1/eNOS (Caveolin-1,CaV1) protein interaction, thereby preventing eNOS overactivation contribution to improving NO bioavailability in PAH rats.CIHH prevents PAH by maintaining eNOS homeostasis in PAH rats.Copyright © 2025 Elsevier Inc. All rights reserved.

基金：
This work was supported by the National Natural Science Foundation of China (No.81800308), Natural Science Foundation of Hebei Province for Innovative Research Group Project (H2021206203), Natural Science Foundation of Hebei Province (No.H2019206246, No.C2021106015), Key Laboratory of Neural and Vascular Biology, Ministry of Education of China (NV20210004) and College student innovation project (USIP2023035, USIP2024136).
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外文
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中科院分区：
出版当年[2025]版：
大类 | 3 区 生物学
小类 | 2 区 生物物理 3 区 生化与分子生物学
最新[2025]版：
大类 | 3 区 生物学
小类 | 2 区 生物物理 3 区 生化与分子生物学
JCR分区：
出版当年[2023]版：
Q1 BIOPHYSICS Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
最新[2023]版：
Q1 BIOPHYSICS Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2025版] 出版当年五年平均 出版前一年[2024版]

第一作者：
第一作者机构： [1]Department of Physiology, Hebei Medical University, Shijiazhuang, 050017, China
通讯作者：
通讯机构： [1]Department of Physiology, Hebei Medical University, Shijiazhuang, 050017, China [2]Hebei Key Laboratory of Neurophysiology, Shijiazhuang, 050017, China [5]The Key Laboratory of Neural and Vascular Biology, Ministry of Education, Shijiazhuang, 050017, China
推荐引用方式(GB/T 7714)：
Li Hai-Shuang,Liu Hui-Jie,Zhang Yu,et al.Chronic intermittent hypobaric hypoxia prevents pulmonary arterial hypertension through maintaining eNOS homeostasis[J].Archives Of Biochemistry And Biophysics.2025,767:110340.doi:10.1016/j.abb.2025.110340.
APA：
Li Hai-Shuang,Liu Hui-Jie,Zhang Yu,Zhang Jing,Yan Han-Yu...&Guan Yue.(2025).Chronic intermittent hypobaric hypoxia prevents pulmonary arterial hypertension through maintaining eNOS homeostasis.Archives Of Biochemistry And Biophysics,767,
MLA：
Li Hai-Shuang,et al."Chronic intermittent hypobaric hypoxia prevents pulmonary arterial hypertension through maintaining eNOS homeostasis".Archives Of Biochemistry And Biophysics 767.(2025):110340

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