机构：[a]Department of Cardiology, The Fourth Hospital of Hebei Medical University, 12 Health Road, Shijiazhuang, Hebei 050011, China临床科室心血管内科河北医科大学第四医院[b]Department of Orthopedics, The Fourth Hospital of Hebei Medical University, 12 Health Road, Shijiazhuang, Hebei 050011, China临床科室骨科河北医科大学第四医院[c]Department of Radiation Oncology, The Fourth Hospital of Hebei Medical University, 12 Health Road, Shijiazhuang, Hebei 050011, China河北医科大学第四医院[d]Department of Medicine Oncology, The Fourth Hospital of Hebei Medical University, 12 Health Road, Shijiazhuang, Hebei 050011, China临床科室肿瘤内科河北医科大学第四医院[e]Department of Emergency, The University of Hong Kong-Shenzhen Hospital, Haiyuan 1st Road, Futian District, Shenzhen, Guangdong 518000, China深圳市康宁医院深圳医学信息中心香港大学深圳医院[f]Department of Cardiology, The Second Hospital of Hebei Medical University, 215 Hepingxi Road, Shijiazhuang, Hebei 050000, China
Radiation-induced heart damage (RIHD) is a side effect of thoracic radiotherapy that can cause late
cardiac problems in patients. Here, we report this side effect can be reduced in rats by chronic intermittent
hypobaric hypoxia (CIHH) treatment prior to irradiation. This pretreatment (PB ?404 mmHg,
PO2 ?84 mmHg, 6 h/day 28 days) improved the functional recovery of the isolated rat hearts that
received cardiac irradiation (20 Gy, single fraction) during Langendorff reperfusion. These tissue slices
showed smaller infarct sizes as compared to those irradiated hearts that received no CIHH pretreatment.
Histopathological examination revealed the ameliorated myocyte necrosis and myocardial fibrosis in the
irradiated hearts by CIHH pretreatment. Biochemical analyses of the total homogenate of heart tissues
demonstrated the reduced concentration of malondialdehyde (a metabolite marker of oxidative stress)
concomitant with the elevated activity of superoxide dismutase (a reactive oxygen specie scavenger) in
irradiated hearts when they had received CIHH pretreatment. Moreover, Western blotting showed two
cellular ER stress markers, GRP78 and CHOP, were increased in irradiated rat hearts; but were reduced
back to normal level by CIHH pretreatment. Taken together, our results demonstrate that CIHH pretreatment
attenuates RIHD in rats. Therefore, patients with cardiac exposure to irradiation might benefit
from similar hypobaric hypoxia treatments to reduce the potential cardiac problems later.
基金：
This
work was supported by the Project of the Key topics planned of
Health Department of Hebei Province (No. 20120372).
语种：
外文
PubmedID：
中科院分区：
出版当年[2016]版：
大类|3 区生物
小类|4 区生化与分子生物学4 区生物物理
最新[2025]版：
大类|4 区生物学
小类|4 区生化与分子生物学4 区生物物理
第一作者：
第一作者机构：[a]Department of Cardiology, The Fourth Hospital of Hebei Medical University, 12 Health Road, Shijiazhuang, Hebei 050011, China
通讯作者：
推荐引用方式(GB/T 7714)：
Ning Zhang,Ling He,Jin Wang,et al.Chronic intermittent hypobaric hypoxia attenuates radiation-induced heart damage in rats.[J].Biochemical And Biophysical Research Communications.2016,doi:10.1016/j.bbrc.2016.06.145.
APA：
Ning Zhang,Ling He,Jin Wang,Yin Guo,Yu Liu...&Yongjun Li.(2016).Chronic intermittent hypobaric hypoxia attenuates radiation-induced heart damage in rats..Biochemical And Biophysical Research Communications,,
MLA：
Ning Zhang,et al."Chronic intermittent hypobaric hypoxia attenuates radiation-induced heart damage in rats.".Biochemical And Biophysical Research Communications .(2016)
