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Roles of non-coding RNAs and exosomal non-coding RNAs, particularly microRNAs, long non-coding RNAs, and circular RNAs, in pathogenic mechanisms behind chronic pain: A review

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收录情况： ◇ SCIE

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机构： [1]Department of Pain and Rehabilitation, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, China [2]Department of Rheumatism and Immunology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, China

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关键词： Pain Chronic pain Noncoding RNAs Exosomes Molecular mechanisms

摘要：

Chronic pain is a significant public health concern that diminishes patients' quality of life and imposes considerable socioeconomic costs. Effective pharmacological treatments for ongoing pain are limited. Recent studies have indicated that various models of chronic pain-such as neuropathic pain, inflammatory pain, and pain associated with cancer-have abnormal levels of long noncoding RNAs (lncRNAs). Research has explored how these abnormal lncRNAs influence the activation of inflammatory cytokines, microRNAs, and other related molecules, which are crucial to the development of chronic pain. These findings suggest that these lncRNAs are vital in chronic pain mechanisms within the spinal cord and dorsal root ganglion following nerve injury. Additionally, exosomes, which can traverse the blood-brain barrier, are considered carriers of noncoding RNAs (ncRNAs) from neurons to systemic circulation. This study aims to summarize the existing knowledge on ncRNAs and exosomal ncRNAs in the context of chronic pain, highlighting potential biomarkers for diagnosis, regulatory roles in disease progression, therapeutic strategies, and clinical implications.Copyright © 2025 Elsevier B.V. All rights reserved.

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出版当年[2025]版：

大类 | 2 区

生物学

小类 | 2 区生化与分子生物学 2 区应用化学 2 区高分子科学

最新[2025]版：

大类 | 2 区

生物学

小类 | 2 区生化与分子生物学 2 区应用化学 2 区高分子科学

JCR分区：

出版当年[2024]版：

Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Q1 CHEMISTRY, APPLIED Q1 POLYMER SCIENCE

最新[2024]版：

Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Q1 CHEMISTRY, APPLIED Q1 POLYMER SCIENCE

影响因子： 8.5 最新[2024版] 8.7 最新五年平均 8.5 出版当年[2025版] 8.7 出版当年五年平均 8.5 出版前一年[2024版]

第一作者：

第一作者机构： [1]Department of Pain and Rehabilitation, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, China

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通讯机构： [1]Department of Pain and Rehabilitation, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, China

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