资源类型:
期刊
WOS体系:
Article
Pubmed体系:
Journal Article
收录情况:
◇ SCIE
文章类型:
论著
机构:
[1]Department of Anesthesiology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China
临床科室
麻醉科
河北医科大学第四医院
ISSN:
0531-5565
关键词:
Causality
Frailty
Respiratory tract infections
Mendelian randomization
National Health and nutrition examination
survey
摘要:
Respiratory tract infections (RTI) remain a challenge to global health, particularly in the frail populations. However, an understanding of the causal relationship between frailty and RTI is limited.Two complementary approaches were used. First, we conducted a cross-sectional analysis to examine the association between frailty index (FI) and RTI, using data from the NHANES 2013-2014. We then introduced Mendelian randomization (MR) using genome-wide association study summary statistics to determine the causality between frailty index, low grip strength, walking pace, light physical activity, and upper (URTI) or lower RTI (LRTI). The primary method of inverse variance weighting and complementary MR methods were used to verify causality. Sensitivity analysis was conducted to confirm the robustness of the primary results.A total of 2249 participants were enrolled in the cross-sectional study. Weighted multivariable-adjusted logistic regression analysis showed that the frailty index was positively associated with RTI after adjusting for covariates (Continuous FI, odds ratio [OR] = 4.95; 95 % confidence interval [CI], 1.69-14.50, P = 0.004; Categorical FI, OR = 1.51 [95 % CI, 1.11-2.06, P = 0.009]). Restricted cubic spline analysis showed a significant increase in the prevalence of RTI when FI was >0.24. The results of the MR analysis supported a causal relationship between the frailty index and LRTI (OR = 1.939 [95 % CI, 1.180-3.186, P = 0.009]). Sensitivity analysis further confirmed the robustness of these findings.Our study identified a potential association between the FI and RTI at both phenotypic and genetic levels. The results revealed a causal relationship between the FI and LRTI.Copyright © 2025. Published by Elsevier Inc.
基金:
This study was supported by the Medical Science Research Project of Hebei (No. 20240953).
被引次数:
1
WOS:
WOS:001473999400001
PubmedID:
40222596
中科院分区:
出版当年[2025]版:
大类
|
3 区
医学
小类
|
4 区
老年医学
最新[2025]版:
大类
|
3 区
医学
小类
|
4 区
老年医学
JCR分区:
出版当年[2024]版:
Q1
GERIATRICS & GERONTOLOGY
最新[2024]版:
Q1
GERIATRICS & GERONTOLOGY
影响因子:
4.3
最新[2024版]
4.2
最新五年平均
4.3
出版当年[2025版]
4.2
出版当年五年平均
4.3
出版前一年[2024版]
第一作者:
Du Wei
第一作者机构:
[1]Department of Anesthesiology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China
通讯作者:
Jia Huiqun
推荐引用方式(GB/T 7714):
Du Wei,Qiao Xi,Jia Weiai,et al.Association of frailty with respiratory tract infections: Evidence from cross-sectional analysis and mendelian randomization[J].Experimental Gerontology.2025,205:112753.doi:10.1016/j.exger.2025.112753.
APA:
Du Wei,Qiao Xi,Jia Weiai,Li Chao&Jia Huiqun.(2025).Association of frailty with respiratory tract infections: Evidence from cross-sectional analysis and mendelian randomization.Experimental Gerontology,205,
MLA:
Du Wei,et al."Association of frailty with respiratory tract infections: Evidence from cross-sectional analysis and mendelian randomization".Experimental Gerontology 205.(2025):112753