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Causal Relationship between Parkinson's Disease with Heart and Vascular Disease: A Two-Sample Mendelian Randomization Study

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收录情况： ◇ SCIE

作者：

机构： [1]Department of Neurosurgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China,

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关键词： Mendelian randomization analysis Parkinson’s disease Myocardial infarction Venous thromboembolism Causality

摘要：

The aim of this study was to investigate the causal relationship between Parkinson's disease (PD) and myocardial infarction (MI), atrial fibrillation and flutter (AF), and venous thromboembolism (VTE) by Mendelian randomization (MR) analysis.By using data from publicly available genome-wide association studies from databases, single nucleotide polymorphisms were screened as instrumental variables, and the MR analysis was finished by inverse-variance weighted (IVW), MR-egger, weighted median methods.The primary IVW method showed a negative association between genetically predicted PD and risk of MI (OR = 0.9989; 95% CI: 0.9980-0.9998; p = 0.02). However, PD was not significantly associated with AF or VTE.This study suggests a negative association between PD with MI, which implies that PD has a protective effect on MI.© 2024 The Author(s). Published by S. Karger AG, Basel.

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中科院分区：

出版当年[2025]版：

大类 | 4 区医学

小类 | 4 区临床神经病学 4 区神经科学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区临床神经病学 4 区神经科学

JCR分区：

出版当年[2024]版：

Q3 CLINICAL NEUROLOGY Q3 NEUROSCIENCES

最新[2024]版：

Q3 CLINICAL NEUROLOGY Q3 NEUROSCIENCES

影响因子： 2.4 最新[2024版] 2.3 最新五年平均 2.4 出版当年[2024版] 2.3 出版当年五年平均 2.1 出版前一年[2023版]

第一作者：

第一作者机构： [1]Department of Neurosurgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China,

通讯作者：

通讯机构： [1]Department of Neurosurgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China,

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