机构：[a]Department of Pathology, Shanxi Cancer Hospital, Taiyuan, China[b]Department of Pathology, Zhongshan Hospital[3]Department of Pathology, School of Basic Sciences & Zhongshan Hospital, Fudan University, Shanghai, China[c]Department of Pathology, Beijing Cancer Hospital, Beijing, China[d]Department of Pathology, The First Hospital Affiliated to AMU (Southwest Hospital), Chongqing, China[e]Department of Pathology, Jiangxi Cancer Hospital, Nanchang, China[f]Department of Pathology, Fourth Hospital of Hebei Medical University, Shijiazhuang, China医技科室病理科河北医科大学第四医院[g]Department of Pathology, The First Affiliated Hospital of Nanchang University, Nanchang, China[h]Department of Pathology, Xijing Hospital, Air Force Medical University (The Fourth Military Medical University), Xi'an, China[i]Department of Pathology, Lanzhou General Hospital of People's Liberation Army, Lanzhou, China[j]Department of Pathology, Lanzhou University Second Hospital, Lanzhou, China[k]Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China[l]Department of Pathology, Yancheng City No.1 People's Hospital, Yancheng, China[m]Department of Pathology, Qilu Hospital of Shandong University, Jinan, China[n]Department of Pathology, The First Affiliated Hospital of Anhui Medical University, Hefei, China[o]Department of Pathology, Changhai Hospital, Naval Medical University, Shanghai, China
Aims: The aim of this study was to explore HER2 status and characteristics in biopsy specimens of gastric cancer (GC) in Chinese population. Methods and results: A total of 27,787 biopsy specimens of GC from 103 hospitals were obtained. Immunohistochemistry (IHC) staining of HER2 was performed. Overall HER2 IHC positive rate was 11.2 %. HER2 positive rate elevated with the increase of age in total patients and both genders. The rates were 7.1 %, 8.1 %, 9.0 %, 10.9 %, 11.8 %, 12.6 %, and 12.1 % when patient age was <= 30, 31-40, 41-50, 51-60, 61-70, 71-80, and > 80, respectively (P < 0.001). In male, the rates were 6.5 %, 8.4 %, 9.6 %, 11.5 %, 12.4 %, 13.3 %, and 12.1 % (P < 0.001). In female, the rates were 7.4 %, 7.9 %, 8.0 %, 9.0 %, 9.6 %, 10.6 %, and 11.9% (P = 0.128). The changes in male were more dramatic than in female (P < 0.001). Furthermore, the proportion of the intestinal type GCs increased with age in total patients and both genders (P < 0.001), and in male the changes were more dramatic (P < 0.001). While the proportion of the diffuse type showed the opposite tendency to that of the intestinal type (P < 0.001). HER2 IHC positive rate showed a positive correlation with the proportion of the intestinal type (r = 0.986, P < 0.001), and a negative correlation with the proportion of the diffuse type (r = 0.984, P < 0.001). Conclusions: The HER2 IHC positive rate showed age variation in biopsy specimens of GC. In male the variation was more dramatic than in female. The variation of HER2 positive rate can be attributed to the age variation of the Lauren subtypes.
基金：
This work was supported by Shanghai Municipal Key
Clinical Specialty (No. shslczdzk01302) and Shanghai Science and
Technology Development Fund (No. 19MC1911000).
第一作者机构：[a]Department of Pathology, Shanxi Cancer Hospital, Taiyuan, China
共同第一作者：
通讯作者：
通讯机构：[b]Department of Pathology, Zhongshan Hospital[*1]Department of Pathology, Zhongshan Hospital,Department of Pathology, School of Basic Sciences & Zhongshan Hospital, Fudan University, Shanghai, 20032, China.
推荐引用方式(GB/T 7714)：
Yanfeng Xi,Chen Xu,Yiqiang Liu,et al.The age variation of HER2 immunohistochemistry positive rate in biopsy specimens of gastric cancer[J].PATHOLOGY RESEARCH AND PRACTICE.2020,216(4):doi:10.1016/j.prp.2020.152882.
APA：
Yanfeng Xi,Chen Xu,Yiqiang Liu,Xiaochu Yan,Chuansheng Huang...&Yingyong Hou.(2020).The age variation of HER2 immunohistochemistry positive rate in biopsy specimens of gastric cancer.PATHOLOGY RESEARCH AND PRACTICE,216,(4)
MLA：
Yanfeng Xi,et al."The age variation of HER2 immunohistochemistry positive rate in biopsy specimens of gastric cancer".PATHOLOGY RESEARCH AND PRACTICE 216..4(2020)
