Two Cu(II) and Co(II)-based coordination polymers based on the N,S-mixed donor ligand: structural characterization and anti-endometrial cancer activity
In this study, two new coordination polymers based on Cu(II) and Co(II) ions as the metal nodes, {Cu(3-PPT)(2)]center dot H2O}(n) (1) and {[Co(3-PPT)(2)]center dot 3CH(3)OH center dot H2O}(n) (2), have been successfully constructed from a pyridine-substituted N-heterocyclic thioamide ligand, namely 3-HPPT (3-HPPT = 4-(3-pyridinyl)-pyrimidine-2-thiol). Furthermore, the treatment activity of complexes 1-2 against HEC-1 endometrial cancer cells was evaluated. First, the CCK-8 assay was performed and the inhibitory effect of compounds 1-2 on HEC-1 cells were determined. Then, the Annexin V-FITC/PI method was performed and the induction activity of the compounds on the cancer cell apoptosis was evaluated. Finally, the PI3K/AKT pathway activation was also measured with western blot.
第一作者机构：[1]Zunyi Med Univ, Peoples Hosp Zunyi 1, Affiliated Hosp 3, Dept Gynaecol & Obstet, Zunyi, Guizhou, Peoples R China
通讯作者：
通讯机构：[3]Hebei Med Univ, Hosp 4, Dept Gynecol Oncol, Shijiazhuang, Hebei, Peoples R China[*1]Department of Gynecologic Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
推荐引用方式(GB/T 7714)：
Zhang Yun-Han,Wang Na,Ma Jing,et al.Two Cu(II) and Co(II)-based coordination polymers based on the N,S-mixed donor ligand: structural characterization and anti-endometrial cancer activity[J].INORGANIC AND NANO-METAL CHEMISTRY.2020,50(12):1221-1227.doi:10.1080/24701556.2020.1745832.
APA：
Zhang, Yun-Han,Wang, Na,Ma, Jing,Kang, Shan,Fan, Xiao-Mei&Zhou, Xinhua.(2020).Two Cu(II) and Co(II)-based coordination polymers based on the N,S-mixed donor ligand: structural characterization and anti-endometrial cancer activity.INORGANIC AND NANO-METAL CHEMISTRY,50,(12)
MLA：
Zhang, Yun-Han,et al."Two Cu(II) and Co(II)-based coordination polymers based on the N,S-mixed donor ligand: structural characterization and anti-endometrial cancer activity".INORGANIC AND NANO-METAL CHEMISTRY 50..12(2020):1221-1227
