机构：[1]Neurology Department, Beijing Hospital, National Center of Gerontology, Dong Dan, Beijing, China[2]MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China[3]Department of Neurology, Peking University First Hospital, Beijing, China[4]Second Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, P.R. China临床科室外二科河北医科大学第四医院[5]The MOH Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology, Dong Dan, Beijing, China[6]Department of Orthopedics, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, P.R. China河北医科大学第四医院整形外科临床科室[7]Internal Medicine Department, Jinzhou Medical University, Liaoning, China
Objective: Chronic stress may lead to augmented incidence rates of coronary and cerebrovascular diseases associated with atherosclerosis. However, few studies have focused on the effect of chronic stress on atherosclerosis plaque formation. Therefore, this study was designed to directly evaluate how chronic stress affects atherosclerosis. Methods: Thirty rabbits were divided into three groups: the control group, balloon-injury operationthornhigh-fat diet model group, and chronic stressthornballoon-injury operationthornhigh-fat diet model group. Physical and social stress were induced, and proteomic methods were applied to identify specific markers. Results: After protein determination, the chronic stressthornballoon-injury operationthornhigh-fat diet model group exhibited significant upregulation of the following apoptosis-related proteins: UBE2K, caspase 3, caspase 9, BAX, P53, and FAS. In particular, real-time polymerase chain reaction showed that the protein expression of caspase 9 was significantly downregulated in the stress group compared with the non-stress groups. However, the other proteins showed significantly increased expression in the stress group. Conclusion: Chronic stress may promote cell apoptosis in the physiopathologic process of atherosclerosis.
基金：
This research was supported by the National
Natural Science Foundation of China under
Grant number 31271097.
语种：
外文
被引次数：
WOS：
PubmedID：
中科院分区：
出版当年[2020]版：
大类|4 区医学
小类|4 区医学：研究与实验4 区药学
最新[2025]版：
大类|4 区医学
小类|4 区医学：研究与实验4 区药学
JCR分区：
出版当年[2020]版：
Q4PHARMACOLOGY & PHARMACYQ4MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版：
Q4MEDICINE, RESEARCH & EXPERIMENTALQ4PHARMACOLOGY & PHARMACY
第一作者机构：[1]Neurology Department, Beijing Hospital, National Center of Gerontology, Dong Dan, Beijing, China
通讯作者：
通讯机构：[1]Neurology Department, Beijing Hospital, National Center of Gerontology, Dong Dan, Beijing, China[*1]Neurology Department, Beijing Hospital, National Center of Gerontology, No. 1 Dahua Road, Dong Dan, Beijing 100730, P.R. China.
推荐引用方式(GB/T 7714)：
Meng Ling-bing,Shan Meng-jie,Yu Ze-mou,et al.Chronic stress: a crucial promoter of cell apoptosis in atherosclerosis[J].JOURNAL OF INTERNATIONAL MEDICAL RESEARCH.2020,48(1):doi:10.1177/0300060518814606.
APA：
Meng, Ling-bing,Shan, Meng-jie,Yu, Ze-mou,Lv, Jian,Qi, Ruo-mei...&Gong, Tao.(2020).Chronic stress: a crucial promoter of cell apoptosis in atherosclerosis.JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,48,(1)
MLA：
Meng, Ling-bing,et al."Chronic stress: a crucial promoter of cell apoptosis in atherosclerosis".JOURNAL OF INTERNATIONAL MEDICAL RESEARCH 48..1(2020)
