机构：[1]Department of Thoracic Surgery, Fourth Hospital of Hebei Medical University, Tumor Hospital of Hebei Province, Shijiazhuang, 050011, Hebei Province, People's Republic of China临床科室胸心外科（胸外科 心脏血管外科）河北医科大学第四医院
Lung cancer remains the leading cause of cancer associated deaths worldwide. Compared with traditional chemotherapy for non-small cell lung cancer (NSCLC), specific targeted therapies are better choices for advanced patients to improve their survival. In this study, we attempted to fabricate Nitroimidazoles (NI) and Hyaluronic acid (HA) co-decorated, cisplatin (DDP) loaded polymeric nanoparticles (PNPs) (NI/HA-DDP-PNPs) and lipidpolymer hybrid nanoparticles (LPNs) (NI/HA-DDP-LPNs) for the facilitated drug delivery at lung tumor regions (hypoxic regions). In vitro cytotoxicity and cellular uptake; In vivo anti-tumor activity and in vivo tissue bio-distribution of PNPs and LPNs were evaluated and compared in lung carcinoma cells and xenograft. Hydrodynamic size of NI/HA-DDP-LPNs was 185.6 +/- 4.7 nm, which is larger than that of NI/HA-DDP-PNPs (136.7 +/- 3.5 nm). The zeta potential of NI/HA-DDP-PNPs (-31.2 +/- 2.7 mV) was more negative than NI/HA-DDP-LPNs (-22.3 +/- 2.1 mV). The peak plasma concentration (C-max) achieved from NI/HA-DDP-PNPs and NI/ HA-DDP-LPNs was 35.2 +/- 1.6 and 37.3 +/- 1.7 mu g/mL. The half-life (T-1/2) of NI/HA-DDP-PNPs and NI/HA-DDPLPNs was 12.03 +/- 0.75 and 11.78 +/- 0.89 h. Area Under Curve (AUC) of NI/HA-DDP-PNPs and NI/HA-DDPLPNs showed no significant difference while greater than other groups. NI/HA-DDP-LPNs exhibited excellent antitumor effect against drug-resistant human lung cancer A549/DDP cells in vitro and in vivo, better than that of NI/HA-DDP-PNPs. Considering that the low toxicity of NI/HA-DDP-LPNs and NI/HA-DDP-PNPs, NI/HA-DDPLPNs could be a more promising system for lung cancer targeted therapy.
基金：
The work was supported by Special Fund for International Scientific
and Technological Cooperation of Hebei Province (18397771D), and Funding for Scientific and Technological Activities of Overseas Scholars
of Hebei Provincial Department of Human Resources and Social
Security (CY201613).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院分区：
出版当年[2020]版：
大类|2 区医学
小类|2 区药学3 区医学：研究与实验
最新[2025]版：
大类|2 区医学
小类|2 区医学：研究与实验2 区药学
JCR分区：
出版当年[2020]版：
Q1PHARMACOLOGY & PHARMACYQ1MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版：
Q1MEDICINE, RESEARCH & EXPERIMENTALQ1PHARMACOLOGY & PHARMACY
第一作者机构：[1]Department of Thoracic Surgery, Fourth Hospital of Hebei Medical University, Tumor Hospital of Hebei Province, Shijiazhuang, 050011, Hebei Province, People's Republic of China
通讯作者：
通讯机构：[1]Department of Thoracic Surgery, Fourth Hospital of Hebei Medical University, Tumor Hospital of Hebei Province, Shijiazhuang, 050011, Hebei Province, People's Republic of China[*1]No. 12 Jiankang Road, Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011, Hebei Province, People's Republic of China.
推荐引用方式(GB/T 7714)：
Chen Ge,Zhang Yaozhong,Deng Haowen,et al.Pursuing for the better lung cancer therapy effect: Comparison of two different kinds of hyaluronic acid and nitroimidazole co-decorated nanomedicines[J].BIOMEDICINE & PHARMACOTHERAPY.2020,125:doi:10.1016/j.biopha.2020.109988.
APA：
Chen, Ge,Zhang, Yaozhong,Deng, Haowen,Tang, Zilong,Mao, Junjie&Wang, Lei.(2020).Pursuing for the better lung cancer therapy effect: Comparison of two different kinds of hyaluronic acid and nitroimidazole co-decorated nanomedicines.BIOMEDICINE & PHARMACOTHERAPY,125,
MLA：
Chen, Ge,et al."Pursuing for the better lung cancer therapy effect: Comparison of two different kinds of hyaluronic acid and nitroimidazole co-decorated nanomedicines".BIOMEDICINE & PHARMACOTHERAPY 125.(2020)
