Lung mixed squamous cell and glandular papilloma (LMSCGP) has no clear signs, clinical symptoms, or imaging features; thus, its diagnosis primarily relies on post-resection histology and immunohistochemistry. Therefore, in this work six case reports are described to review the clinicopathologic characteristics, diagnosis, treatment, and prognosis. Here, we report the clinical symptoms, imaging features, pathologic characteristics, and follow-up data of six LMSCGP patients. Among the 6 patients, 4 were males and 2 were females, with a mean age of 52.7 years (39-67 years). These patients accounted for 0.0827% of patients who underwent thoracic surgery in the same period (6/7357). Preoperative diagnosis indicated cancer or most likely cancer in 3 patients, benign lesions in 3 patients, and bronchial adenoma in 1 patient. All 6 patients underwent surgery, consisting of wedge resection in 3 patients and lobectomy in the other 3 patients. Hilar lymph node metastasis was not identified during postoperative pathologic diagnosis. Conclusion: LMSCGP is a rare lung tumor with a certain heterogeneity that makes definite preoperative diagnosis difficult. Complete surgical resection is the preferred treatment choice and results in a good prognosis in most cases.