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Comparison of neoadjuvant chemoradiotherapy and neoadjuvant chemotherapy for esophageal cancer: a meta-analysis

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收录情况： ◇ SCIE

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机构： [1]Department of Radiation Oncology, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, PR China [2]Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, PR China [3]Department of Radiation Oncology, Duke University, Durham, NC 27708, USA

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关键词： chemoradiotherapy chemotherapy complication esophageal neoplasms meta-analysis neoadjuvant overall survival pathological complete regression progression-free survival R0 resection rate

摘要：

Aim: To compare the clinical efficacy of neoadjuvant chemoradiotherapy (nCRT) and neoadjuvant chemotherapy (nCT) for esophageal cancer. Methods: Randomized controlled trials reporting on the comparison of nCRT and nCT for esophageal cancer were identified. Results: Three eligible randomized controlled trials were identified and included with a total of 375 patients (189 nCRT, 186 nCT). Outcomes showed that compared with nCT group, R0 resection and pathologic complete response (pCR) rates were significantly increased in nCRT group. However, no significant difference was seen in 3- and 5-year progression-free survival or 3- and 5-year overall survival. Conclusion: The addition of radiotherapy to neoadjuvant chemotherapy results in higher R0 resection rate and pCR rate, without significantly impacting survival.

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出版当年[2019]版：

大类 | 4 区医学

小类 | 4 区肿瘤学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区肿瘤学

JCR分区：

出版当年[2019]版：

Q3 ONCOLOGY

最新[2023]版：

Q2 ONCOLOGY

影响因子： 3 最新[2023版] 2.9 最新五年平均 2.66 出版当年[2019版] 2.379 出版当年五年平均 2.279 出版前一年[2018版] 3.404 出版后一年[2020版]

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第一作者机构： [1]Department of Radiation Oncology, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, PR China

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