机构：[1]Clinical Laboratory, The Fourth Hospital of Hebei Medical University, Shijiazhuang, People’s Republic of China河北医科大学第四医院[2]Research Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, People’s Republic of China河北医科大学第四医院[3]Department of Infection Management, The Fourth Hospital of Hebei Medical University, Shijiazhuang, People’s Republic of China河北医科大学第四医院[4]Department of Biotherapy, The Fourth Hospital of Hebei Medical University, Shijiazhuang, People’s Republic of China河北医科大学第四医院
Objectives: Burkitt lymphoma is one of the most common types of haematopoietic malignancy in children and adolescents. Mda-7/IL-24 had been identified as a differentiation inducer of Burkitt lymphoma cells. Previous studies have revealed that knockdown of C-myb can also lead to the terminal differentiation of Burkitt lymphoma cells. The aim of the present study was to investigate the correlation between the expression of Mda-7/IL-24 and C-myb, as well as their prognostic significance, for Burkitt lymphoma patients. Methods: The tumour tissues were collected from 59 cases of Burkitt lymphoma patients and detected with Western blotting and immunohistochemistry. Results: The results showed that the expression of Mda-7/IL-24 was lower, whereas the expression of C-myb was higher in Burkitt lymphoma tissues compared to specimens of normal lymph node tissues. Furthermore, C-myb expression was negatively correlated with Mda-7/IL-24 expression at the protein level in Burkitt lymphoma tissues and cell lines. Both the expression of Mda-7/IL-24 and C-myb in Burkitt lymphoma tissues was associated with some clinicopathological parameters, such as clinical stage, infiltration in the bone marrow, Ki67 and overall survival rates. Conclusion: These results indicated that low expression of Mda-7/IL-24 along with high expression of C-myb are predictors for poor prognosis of Burkitt lymphoma patients; this outcome suggests that Mda-7/IL-24 and C-myb might be potential targets for clinical treatment of Burkitt lymphoma.
基金：
Natural Science
Foundation of China (grant no. 81703073), the Natural
Science Foundation of Hebei Province (grant no.
H2015206376), and Health Department of Hebei Province
(no. 20160171).
第一作者机构：[1]Clinical Laboratory, The Fourth Hospital of Hebei Medical University, Shijiazhuang, People’s Republic of China
通讯作者：
通讯机构：[2]Research Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, People’s Republic of China[*1]Research Center, The Fourth Hospital of Hebei Medical University, 12# Jiankang Road, Shijiazhuang, Hebei 050011, People’s Republic of China
推荐引用方式(GB/T 7714)：
Ma Ming,Zhao Riyang,Yang Xingxiao,et al.Low expression of Mda-7/IL-24 and high expression of C-myb in tumour tissues are predictors of poor prognosis for Burkitt lymphoma patients[J].HEMATOLOGY.2018,23(8):448-455.doi:10.1080/10245332.2018.1435046.
APA：
Ma, Ming,Zhao, Riyang,Yang, Xingxiao,Zhao, Lianmei,Liu, Lihua...&Shan, Baoen.(2018).Low expression of Mda-7/IL-24 and high expression of C-myb in tumour tissues are predictors of poor prognosis for Burkitt lymphoma patients.HEMATOLOGY,23,(8)
MLA：
Ma, Ming,et al."Low expression of Mda-7/IL-24 and high expression of C-myb in tumour tissues are predictors of poor prognosis for Burkitt lymphoma patients".HEMATOLOGY 23..8(2018):448-455
