MicroRNAs (miRs) function as tumor suppressors or oncogenes in tumor development and progression. The present study reported that miR-409-3p was significantly downregulated in human papillary thyroid carcinoma (PTC) tissues and cell lines. Overexpression of miR-409-3p suppressed cell proliferation and induced cell cycle G(0)/G(1) phase arrest in PTC cells. Further study revealed that the transcriptional regulator cyclin D2 was a target of miR-409-3p, as miR-409-3p bound directly to its 3-untranslated region and the miR-409-3p mimic reduced the protein expression levels of cyclin D2. In addition, restoration of cyclin D2 expression reversed the inhibitive effect of miR-409-3p on PTC cells. To the best of our knowledge, these findings demonstrate for the first time that miR-409-3p functions as a tumor suppressor in PTC and could serve as an efficient agent for therapy of PTC.
第一作者机构：[1]Department of Head and Neck Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, P.R. China
通讯作者：
通讯机构：[1]Department of Head and Neck Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, P.R. China[*1]Department of Head and Neck Surgery, The Fourth Hospital of Hebei Medical University, 12 Health Road, Shijiazhuang, Hebei 050000, P.R. China
推荐引用方式(GB/T 7714)：
Zhao Zhijun,Yang Fei,Liu Yan,et al.MicroRNA-409-3p suppresses cell proliferation and cell cycle progression by targeting cyclin D2 in papillary thyroid carcinoma[J].ONCOLOGY LETTERS.2018,16(4):5237-5242.doi:10.3892/ol.2018.9246.
APA：
Zhao, Zhijun,Yang, Fei,Liu, Yan,Fu, Kai&Jing, Shanghua.(2018).MicroRNA-409-3p suppresses cell proliferation and cell cycle progression by targeting cyclin D2 in papillary thyroid carcinoma.ONCOLOGY LETTERS,16,(4)
MLA：
Zhao, Zhijun,et al."MicroRNA-409-3p suppresses cell proliferation and cell cycle progression by targeting cyclin D2 in papillary thyroid carcinoma".ONCOLOGY LETTERS 16..4(2018):5237-5242
