机构：[1]Key Laboratory of Cancer Prevention and Therapy, Department of Esophageal Cancer, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital[2]Department of Obstetrics and Gynecology, Tianjin Medical University General Hospital, Tianjin 300070[3]Department of Thoracic Surgery, The Fourth Affiliated Hospital, Hebei Medical University, Shijiazhuang, Hebei 050017, P.R. China河北医科大学第四医院胸五科临床科室
As a mitotic spindle checkpoint gene, baculoviral IAP repeat containing 5 (BIRC5) serves pivotal roles in the development of various types of malignant tumors. In the present study, the expression of BIRC5 in patients with different stages of esophageal squamous cell cancer (ESCC) was investigated. The effect of BIRC5 on the migratory and invasive abilities of different ESCC cell lines was analyzed. Additionally, the effect of BIRC5 on the angiogenesis-associated factor vascular endothelial growth factor, brain-specific angiogenesis inhibitor 1 and methyl-CpG binding domain protein 2 was examined. In addition, the interaction between BIRC5 and the phosphatidylinositol 3-kinase (PI3K)/Akt pathway was analyzed. It was determined that BIRC5 is able to inhibit the migration and invasion of tumor cells, and regulate the expression of angiogenesis-associated factors. In addition, the PI3K/Akt signaling pathway is able to regulate the expression of BIRC5, which affects the development of ESCC.
第一作者机构：[1]Key Laboratory of Cancer Prevention and Therapy, Department of Esophageal Cancer, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital
共同第一作者：
通讯作者：
通讯机构：[1]Key Laboratory of Cancer Prevention and Therapy, Department of Esophageal Cancer, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital[*1]Key Laboratory of Cancer Prevention and Therapy, Department of Esophageal Cancer, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Huan‑Hu‑Xi Road, Ti‑Yuan‑Bei, Hexi, Tianjin 300070, P.R. China
推荐引用方式(GB/T 7714)：
Shang Xiaobin,Liu Guoyan,Zhang Yuefeng,et al.Downregulation of BIRC5 inhibits the migration and invasion of esophageal cancer cells by interacting with the PI3K/Akt signaling pathway[J].ONCOLOGY LETTERS.2018,16(3):3373-3379.doi:10.3892/ol.2018.8986.
APA：
Shang, Xiaobin,Liu, Guoyan,Zhang, Yuefeng,Tang, Peng,Zhang, Hongdian...&Yu, Zhentao.(2018).Downregulation of BIRC5 inhibits the migration and invasion of esophageal cancer cells by interacting with the PI3K/Akt signaling pathway.ONCOLOGY LETTERS,16,(3)
MLA：
Shang, Xiaobin,et al."Downregulation of BIRC5 inhibits the migration and invasion of esophageal cancer cells by interacting with the PI3K/Akt signaling pathway".ONCOLOGY LETTERS 16..3(2018):3373-3379
