机构：[1]Department of General Surgery, Fourth Affiliated Hospital, Hebei Medical University, Shijiazhuang, Hebei, China河北医科大学第四医院[2]Department of Oncology, The First Hospital of Shijiazhuang, Shijiazhuang, Hebei, China
Platelet-activating factor acetylhydrolase IB subunit beta (PAFAH1B2) plays important roles in inflammation and anaphylaxis. However, its primary function in pancreatic cancer remains unclear. In the current study, we report that PAFAHIB2 is overexpressed in pancreatic ductal adenocarcinoma (PDAC) and correlated inversely with patient survival. PAFAH1B2 overexpression induced epithelial mesenchymal transition (EMT), migration and invasion in vitro and metastasis in vivo. Conversely, silencing PAFAH1B2 inhibited these aggressive phenotypes. Moreover, PAFAH1B2 overexpression in PDAC cells was directly mediated by HIF1a. PAFAH1B2 expression in PDAC clinical specimens correlated positively with HIF1a expression. Overall, our results defined PAFAHIB2 as a target gene of HIF1a and a critical driver of PDAC metastatic behaviors. (C) 2018 The Authors. Published by Elsevier Inc.
基金：
Key Program of Natural Science
Foundation of Hebei (grants11YCYBYC18400).
第一作者机构：[1]Department of General Surgery, Fourth Affiliated Hospital, Hebei Medical University, Shijiazhuang, Hebei, China
通讯作者：
通讯机构：[1]Department of General Surgery, Fourth Affiliated Hospital, Hebei Medical University, Shijiazhuang, Hebei, China[*1]Department of General Surgery, Fourth Affiliated Hospital, Hebei Medical University, Jiankang District ,Shijiazhuang, Hebei, China.
推荐引用方式(GB/T 7714)：
Ma Can,Guo Yan,Zhang Yan,et al.PAFAH1B2 is a HIF1a target gene and promotes metastasis in pancreatic cancer[J].BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.2018,501(3):654-660.doi:10.1016/j.bbrc.2018.05.039.
APA：
Ma, Can,Guo, Yan,Zhang, Yan,Duo, Aixia,Jia, Yitao...&Li, Binghui.(2018).PAFAH1B2 is a HIF1a target gene and promotes metastasis in pancreatic cancer.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,501,(3)
MLA：
Ma, Can,et al."PAFAH1B2 is a HIF1a target gene and promotes metastasis in pancreatic cancer".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 501..3(2018):654-660
