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Expression and significance of autonomic nerves and 9 nicotinic acetylcholine receptor in colorectal cancer

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机构: [1]Second Department of Surgery, Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011 [2]Department of Pediatric Surgery, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000 [3]Department of Oncology, Hebei General Hospital, Shijiazhuang, Hebei 050051 [4]Department of Cardiovascular Surgery, Central Hospital of Handan, Handan, Hebei 056001 [5]Research Center, Fourth Hospital of Hebei Medical University,Shijiazhuang, Hebei 050011, P.R. China
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关键词: colorectal cancer sympathetic nervous parasympathetic nervous 9 nicotinic acetylcholine receptor

摘要:
The present study evaluated the distribution of sympathetic and parasympathetic nerves and the expression of the 9 nicotinic acetylcholine receptor (9nAChR) and investigated their potential association with colorectal cancer (CRC) development. The distribution of autonomic nerves and 9nAChR in CRC was detected by immunohistochemistry, which was then used to analyze their association with clinicopathological parameters and prognosis. Sympathetic fibers were primarily observed in the stroma adjacent to cancer cells, whereas parasympathetic fibers were primarily observed in the stroma away from cancer cells. Patients with samples positive for sympathetic nerve fibers had less lymph node invasion and a better prognosis compared with patients with samples negative for sympathetic nerve fibers. The expression of parasympathetic nerves in patients >60 years old was increased compared with patients 60 years old. The expression of parasympathetic nerves in patients with lymph node invasion was increased compared with patients without lymph node invasion. The detection of parasympathetic nerves gradually increased as CRC (T stage) advanced. Patients with parasympathetic negative samples had better prognoses compared with patients with parasympathetic positive samples. The expression of 9nAChR was principally localized in cellular membranes and the cytoplasm of CRC tissues and it was revealed to have a positive association with the number of parasympathetic nerves. Increased 9nAChR expression was observed in patients >60 years old compared with patients <60 years old. The detection rate of 9nAChR in tissues from patients with lymph node invasion was increased compared with patients without lymph node invasion. The detection of 9nAChR gradually increased as the CRC stage advanced. The prognoses for patients with 9nAChR negative tissue were improved compared with the prognoses for patients with 9nAChR positive tissue. Sympathetic nerves were primarily detected in the early phases of CRC and indicated a good prognosis. Parasympathetic nerves and 9nAChR were principally observed in the late phases of cancer and indicated a poor prognosis. The present study revealed that parasympathetic nerves may promote the progression of CRC through 9nAChR.

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出版当年[2018]版:
大类 | 4 区 医学
小类 | 4 区 医学:研究与实验 4 区 肿瘤学
最新[2025]版:
大类 | 4 区 医学
小类 | 4 区 医学:研究与实验 4 区 肿瘤学
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出版当年[2018]版:
Q3 MEDICINE, RESEARCH & EXPERIMENTAL Q4 ONCOLOGY
最新[2024]版:
Q2 MEDICINE, RESEARCH & EXPERIMENTAL Q2 ONCOLOGY

影响因子: 最新[2024版] 最新五年平均 出版当年[2018版] 出版当年五年平均 出版前一年[2017版] 出版后一年[2019版]

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第一作者机构: [1]Second Department of Surgery, Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011 [2]Department of Pediatric Surgery, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000
通讯作者:
通讯机构: [1]Second Department of Surgery, Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011 [*1]Second Department of Surgery, Fourth Hospital of Hebei Medical University, 169 Tianshan Road, Shijiazhuang, Hebei 050011, P.R. China
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