机构：[1]Second Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050035临床科室外二科河北医科大学第四医院[2]Fifth Department of Oncology, The First Hospital of Shijiazhuang, Shijiazhuang, Hebei 050011[3]Department of Endoscopy, Xingtai General Hospital of Hebei Medical University, Xingtai, Hebei 054001[4]Third Department of Oncology, Hebei General Hospital, Shijiazhuang, Hebei 050051[5]Department of Orthopedics, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050035, P.R. China河北医科大学第四医院
The present study aimed to evaluate the expression of human epidermal growth factor receptor (HER4) isoforms and their ligand neuregulin 1 (NRG1) isoforms in human primary colorectal cancer (CRC). The mRNA expression of HER4 isoforms JM-a, JM-b, CYT1 and CYT2, and their ligand isoforms NRG1 I, II and III in CRC tissues and adjacent normal tissues were quantified by reverse transcription-quantitative polymerase chain reaction analysis. Univariate analysis and logistic regression analysis were performed to analyze the association between HER4 and NRG1 expression and lymph node metastasis in CRC. The expression levels of CYT1 (P=0.002), CYT2 (P=0.002) and NRG1 type III (P<0.001) were significantly higher in the CRC tissues than in the adjacent normal tissues. The expression of CYT2 was correlated with tumor stage (P=0.018), lymph node status (P=0.015) and tumor-node-metastasis (P=0.038) in CRC. The expression of NRG1III was correlated with lymph node metastasis, and the expression of CYT2 was associated with the expression of NRG1III (r=0.691, P<0.01). The logistic regression analysis indicated that expression of CYT2 >50 was a risk factor for lymph node metastasis in CRC. In conclusion the expression levels of CYT1, CYT2 and NRG1III were upregulated in CRC. An expression of CYT-2 >50 was identified as a risk factor for lymph node metastasis in CRC. Therefore, CY-2 and NRG1III may be involved in the progression of CRC.
基金：
Natural Science Foundation of
Hebei Province of China (grant no. H2016307010).
第一作者机构：[1]Second Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050035[2]Fifth Department of Oncology, The First Hospital of Shijiazhuang, Shijiazhuang, Hebei 050011
通讯作者：
通讯机构：[1]Second Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050035[*1]Second Department of Surgery, The Fourth Hospital of Hebei Medical University, 169 Tianshan Road, Shijiazhuang, Hebei 050035, P.R. China
推荐引用方式(GB/T 7714)：
Guo Yan,Duan Zhihui,Jia Yitao,et al.HER4 isoform CYT2 and its ligand NRG1III are expressed at high levels in human colorectal cancer[J].ONCOLOGY LETTERS.2018,15(5):6629-6635.doi:10.3892/ol.2018.8124.
APA：
Guo, Yan,Duan, Zhihui,Jia, Yitao,Ren, Chaoying,Lv, Jian...&Li, Zhongxin.(2018).HER4 isoform CYT2 and its ligand NRG1III are expressed at high levels in human colorectal cancer.ONCOLOGY LETTERS,15,(5)
MLA：
Guo, Yan,et al."HER4 isoform CYT2 and its ligand NRG1III are expressed at high levels in human colorectal cancer".ONCOLOGY LETTERS 15..5(2018):6629-6635
