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Lipopolysaccharide levels adherent to PM2.5 play an important role in particulate matter induced-immunosuppressive effects in mouse splenocytes

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收录情况： ◇ SCIE

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机构： [1]Department of Immunology and Parasitology, School of Medicine, University of Occupational and Environmental Health, Japan, 1‐1 Iseigaoka, Yahatanishi‐ku, Kitakyushu 807‐8555, Japan [2]Department of Clinical Laboratory, the Fourth Hospital of Hebei Medical University, No. 169 Tian Shan Street, Shijiazhuang 050035, China [3]Department of Health Sciences, Oita University of Nursing and Health Sciences, 2944‐9 Notsuharu, Oita 870‐1201, Japan [4]Department of Environmental Health, School of Public Health, China Medical University, Shenyang 110122, China

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关键词： HO-1 immune suppression Keap1 LPS Nrf2 PM2 5

摘要：

Epidemiological studies show that exposure to ambient particulate matter (PM) is associated with serious adverse health effects, including, but not limited to, those on the respiratory system. In the present study, we investigated the splenic response in mice administered PM of 2.5m diameter (PM2.5). Male BALB/c mice (7 or 8 weeks old) were intratracheally administered PM2.5 (0.1mg) four times, at 2week intervals, and dissected 24h after the final administration. The effect of six types of PM2.5, collected in Shenyang or Beijing (China) and Kitakyushu (Japan), on splenocytes was examined. Our results revealed a strong correlation between the levels of lipopolysaccharide (LPS), but not that of -glucan and polycyclic aromatic hydrocarbons, attached to PM2.5 and the effect of PM2.5 on cell activity. PM2.5 with a low amount of LPS (PM2.5LL) reduced splenocyte mitogen-induced proliferation and cytokine production compared with that in control mice. The suppressive effects of PM2.5LL on proliferation and interleukin-2 production in splenocytes were rescued by the antioxidant N-acetylcysteine. Expression of heme oxygenase-1 was elevated after PM2.5LL administration, particularly in CD11b(+)cells, while no elevation was observed in CD4(+), CD8(+) or B220(+) cells. Further, dissociation of the nuclear factor erythroid 2-related factor 2 from Kelch-like ECH-associating protein 1 was observed in splenocytes of PM2.5LL-administered mice. These data suggest that LPS attached to PM2.5 modulates the splenocyte immune responses to PM2.5. Exposure to ambient particulate matter (PM) is associated with serious adverse health effects. We investigated the splenic response in mice administered PM of 2.5m diameter (PM2.5) with various molecules attached, obtained from different sources. PM2.5 with a low amount of lipopolysaccharide significantly reduced splenocyte mitogen-induced proliferation and cytokine production in mice; this effect was abrogated by antioxidant treatments. Our findings indicate that lipopolysaccharide adhering to PM2.5 modulates the immune response induced by these particles in splenocytes.

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出版当年[2018]版：

大类 | 3 区医学

小类 | 3 区毒理学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区毒理学

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出版当年[2018]版：

Q2 TOXICOLOGY

最新[2023]版：

Q3 TOXICOLOGY

影响因子： 2.7 最新[2023版] 3.2 最新五年平均 3.065 出版当年[2018版] 2.975 出版当年五年平均 2.909 出版前一年[2017版] 2.997 出版后一年[2019版]

第一作者：

第一作者机构： [1]Department of Immunology and Parasitology, School of Medicine, University of Occupational and Environmental Health, Japan, 1‐1 Iseigaoka, Yahatanishi‐ku, Kitakyushu 807‐8555, Japan

通讯作者：

通讯机构： [1]Department of Immunology and Parasitology, School of Medicine, University of Occupational and Environmental Health, Japan, 1‐1 Iseigaoka, Yahatanishi‐ku, Kitakyushu 807‐8555, Japan [*1]Department of Immunology and Parasitology, School of Medicine, University of Occupational and Environmental Health, 1‐1 Iseigaoka, Yahatanishi‐ku, Kitakyushu 807‐8555, Japan.

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Lipopolysaccharide levels adherent to PM2.5 play an important role in particulate matter induced-immunosuppressive effects in mouse splenocytes

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