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The diagnostic and prognostic value of interleukin-10 in cerebrospinal fluid for central nervous system lymphoma: a meta-analysis

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收录情况： ◇ SCIE

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机构： [1]Department of Hematology, Laoshan Branch of No. 401 Hospital of Chinese People’s Liberation Army (PLA), Qingdao, China [2]Department of Hematology, Chinese PLA General Hospital, Beijing, China [3]Department of Hematology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China

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关键词： Cerebrospinal fluid interleukin-10 central nervous system lymphoma meta-analysis diagnosis prognosis

摘要：

Central nervous system lymphoma (CNSL) presents diagnostic and prognostic challenges. The aim of this meta-analysis was to evaluate the diagnostic and prognostic value of interleukin (IL)-10 in cerebrospinal fluid (CSF) for CNSL comprehensively. PubMed and Cochrane Library databases were searched through September 2016. Four studies with 212 CNSL patients and 262 control patients were included. The pooled sensitivity and specificity of CSF IL-10 for diagnosing CNSL were 81% (95% CI: 66-91%) and 97% (95% CI: 83-100%), respectively. The summary receiver operating characteristic (SROC) curve indicated that the area under the curve was 0.95 (0.93-0.97). The ROC curve based on extracted individual data showed that the optimal cutoff value was 6.88pg/ml. Moreover, elevated CSF IL-10 was found to be associated with shorter progression-free survival (hazard ratio: 2.89, 95% CI: 1.13-7.41, p=.027). In conclusion, our meta-analysis showed that CSF IL-10 is an effective diagnostic and prognostic biomarker for CNSL.

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出版当年[2017]版：

大类 | 3 区医学

小类 | 3 区血液学 3 区肿瘤学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区血液学 4 区肿瘤学

JCR分区：

出版当年[2017]版：

Q2 HEMATOLOGY Q3 ONCOLOGY

最新[2023]版：

Q3 HEMATOLOGY Q3 ONCOLOGY

影响因子： 2.2 最新[2023版] 2.5 最新五年平均 2.644 出版当年[2017版] 2.493 出版当年五年平均 2.755 出版前一年[2016版] 2.674 出版后一年[2018版]

第一作者：

第一作者机构： [1]Department of Hematology, Laoshan Branch of No. 401 Hospital of Chinese People’s Liberation Army (PLA), Qingdao, China [2]Department of Hematology, Chinese PLA General Hospital, Beijing, China

共同第一作者：

通讯作者：

通讯机构： [1]Department of Hematology, Laoshan Branch of No. 401 Hospital of Chinese People’s Liberation Army (PLA), Qingdao, China [2]Department of Hematology, Chinese PLA General Hospital, Beijing, China [*1]Department of Hematology, Chinese People’s Liberation Army (PLA) General Hospital, 28 Fuxing Road, Beijing 100853, China [*2]Department of Hematology, Laoshan Branch of No. 401 Hospital of Chinese PLA, 109 Laoshan Road, Qingdao 266101, China

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