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Patterns and Mechanisms of Artificial Kidney Failure during Continuous Renal Replacement Therapy

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收录情况： ◇ SCIE

作者：

机构： [1]Department of Nephrology, West China Hospital of Sichuan University, Sichuan, Chengdu [2]Department of Intensive Care Unit, Fourth Hospital of Hebei Medical University, Shijiazhuang , Hebei, China [3]Department of Intensive Care Unit, Austin Hospital, Heidelberg , Australia

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关键词： Artificial kidney failure Circuit pressure Access outflow dysfunction Transmembrane pressure Critical illness

摘要：

Background: We aimed to describe the previously unstudied relationship between circuit pressures and circuit clotting, here labeled as 'artificial kidney failure' (AKF), in patients receiving continuous renal replacement therapy (CRRT). Methods: We performed an observational study of CRRT-treated critically ill patients to continuously record the multiple CRRT circuit pressures. Results: Three patterns of access outflow dysfunction (AOD) were also noted: severe, moderate and mild. Compared with circuits without AOD, circuits experiencing at least one AOD episode had shorter lifespans (14.2 +/- 12.7 vs. 21.3 +/- 16.5 h, p = 0.057). This effect was more obvious with moderate or severe AOD (8.7 +/- 4.6 vs. 20.6 +/- 15.7 h, p = 0.007). If any AOD events occurred within the first 4 h, the sensitivity and specificity in predicting early-immediate AKF were 53.4 and 94.4%, respectively. Conclusions: Early and intermediate AKF during CRRT is most likely dependent on AOD, which is a frequent event with variable severity. (C) 2015 S. Karger AG, Basel

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出版当年[2016]版：

大类 | 4 区医学

小类 | 4 区血液学 4 区泌尿学与肾脏学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区血液学 4 区泌尿学与肾脏学

JCR分区：

出版当年[2016]版：

Q3 UROLOGY & NEPHROLOGY Q4 HEMATOLOGY

最新[2023]版：

Q2 UROLOGY & NEPHROLOGY Q3 HEMATOLOGY

影响因子： 2.2 最新[2023版] 2.5 最新五年平均 1.535 出版当年[2016版] 1.693 出版当年五年平均 1.404 出版前一年[2015版] 1.919 出版后一年[2017版]

第一作者：

第一作者机构： [1]Department of Nephrology, West China Hospital of Sichuan University, Sichuan, Chengdu [3]Department of Intensive Care Unit, Austin Hospital, Heidelberg , Australia

通讯作者：

通讯机构： [3]Department of Intensive Care Unit, Austin Hospital, Heidelberg , Australia [*1]Department of Intensive Care Unit,Austin Health, 145 Studley Road,Heidelberg, VIC 3084 (Australia)

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Patterns and Mechanisms of Artificial Kidney Failure during Continuous Renal Replacement Therapy

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