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Impaired response of regulator of G alpha q signaling-2 mRNA to angiotensin II and hypertensive renal injury in Dahl salt-sensitive rats

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文献详情

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收录情况： ◇ SCIE

作者：
Wu, Yaqiong[1] * ; Takahashi, Hidenori[2] ; Suzuki, Etsu[3] ; Kruzliak, Peter[4] ; Soucek, Miroslav[4] ; Uehara, Yoshio[5,*1] ;
机构： [1]Department of Cardiology, Fourth Hospital of Hebei Medical University, Shijiazhuang, China [2]Department of Ophthalmology, University of Tokyo School of Medicine, Tokyo, Japan [3]Institute of Medical Science, St Marianna University School of Medicine, Miyamae-ku, Kawasaki, Japan [4]International Clinical Research Center, St Anne´s University Hospital and Masaryk University, Brno, Czech Republic [5]Department of Food and Nutrition, Division of Clinical Nutrition, Faculty of Home Economics, Kyoritsu Women’s University, Tokyo, Japan
出处：
DOI： 10.1038/hr.2015.132
ISSN：

关键词： angiotensin Dahl rat kidney damage RGS2 salt hypertension

摘要：
Dahl salt-sensitive (Dahl S) rats are prone to salt-dependent hypertension with severe organ damage, including stroke, cardiac failure and renal insufficiency. The mechanism for this susceptibility to kidney injury has not been elucidated. The present study proposed that an upregulation of intracellular signaling of angiotensin II (Ang-II) is responsible for the susceptibility to hypertensive kidney injury in Dahl S rats. Spontaneously hypertensive rats exhibited higher systolic blood pressure (SBP) and lower kidney damage than Dahl S rats fed a high-salt diet for 2 weeks. Ang-II infusion for 4 weeks significantly increased SBP in Dahl S and Dahl salt-resistant (Dahl R) rats fed a low-salt diet. The increase in SBP in Dahl S rats was associated with significant kidney injury with greater glomerular sclerosis (P < 0.001). The expression of regulatory protein of G alpha q signaling-2 (RGS2) mRNA in the aortic walls in response to Ang-II infusion was lower in Dahl S than Dahl R rats (P < 0.05). Ang-II significantly increased RGS2 mRNA in the aorta in Dahl R rats, but the response was apparently blunted in Dahl S rats. These results suggest that Dahl S rats exhibit a blunted RGS2 response to Ang-II, and this blunted response may be partially responsible for the susceptibility to renal injury in Dahl S rats.

语种：
外文
被引次数：
WOS：
PubmedID：
中科院分区：
出版当年[2016]版：
大类 | 3 区 医学
小类 | 3 区 外周血管病
最新[2025]版：
大类 | 3 区 医学
小类 | 3 区 外周血管病
JCR分区：
出版当年[2016]版：
Q2 PERIPHERAL VASCULAR DISEASE
最新[2024]版：
Q1 PERIPHERAL VASCULAR DISEASE

影响因子： 最新[2024版] 最新五年平均 出版当年[2016版] 出版当年五年平均 出版前一年[2015版] 出版后一年[2017版]

第一作者：
第一作者机构： [1]Department of Cardiology, Fourth Hospital of Hebei Medical University, Shijiazhuang, China
通讯作者：
通讯机构： [5]Department of Food and Nutrition, Division of Clinical Nutrition, Faculty of Home Economics, Kyoritsu Women’s University, Tokyo, Japan [*1]Division of Clinical Nutrition, Faculty of Home Economics, Kyoritsu Women’s University, 2-2-1 Hitotsubashi, Chiyoda-ku, Tokyo 101-8437, Japan
推荐引用方式(GB/T 7714)：
Wu Yaqiong,Takahashi Hidenori,Suzuki Etsu,et al.Impaired response of regulator of G alpha q signaling-2 mRNA to angiotensin II and hypertensive renal injury in Dahl salt-sensitive rats[J].HYPERTENSION RESEARCH.2016,39(4):210-216.doi:10.1038/hr.2015.132.
APA：
Wu, Yaqiong,Takahashi, Hidenori,Suzuki, Etsu,Kruzliak, Peter,Soucek, Miroslav&Uehara, Yoshio.(2016).Impaired response of regulator of G alpha q signaling-2 mRNA to angiotensin II and hypertensive renal injury in Dahl salt-sensitive rats.HYPERTENSION RESEARCH,39,(4)
MLA：
Wu, Yaqiong,et al."Impaired response of regulator of G alpha q signaling-2 mRNA to angiotensin II and hypertensive renal injury in Dahl salt-sensitive rats".HYPERTENSION RESEARCH 39..4(2016):210-216

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