Interleukin (IL)-27 is an important pleiotropic immunological regulator for having dual effects on the immune responses. Several distinct findings have been highlighted that in certain conditions, neutralizing IL-27 or its subunit IL-27p28 might be a useful strategy to limit inflammation. Recently more insights have revealed that IL-27 could also exert potent inhibitory functions in some other immune circumstances including virus infection and tumor immunity. In this review, we describe IL-27 receptor subunits and the mechanisms of individual IL-27, and summarize the advances of their preclinical application trials. In addition, the potential role of IL-27 as a clinical therapeutic target will also be discussed. (C) 2015 Elsevier B.V. All rights reserved.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81201607]; Scientifical Fund for Outstanding People of Hebei Province [H2014206320]; Postdoctoral Fund of ChinaChina Postdoctoral Science Foundation [2013M540883]
第一作者机构：[1]Department of Biotherapy, Fourth Hospital of Hebei Medical University and Hebei Cancer Institute, Shijiazhuang, China
通讯作者：
通讯机构：[1]Department of Biotherapy, Fourth Hospital of Hebei Medical University and Hebei Cancer Institute, Shijiazhuang, China[*1]Department of Biotherapy, FourthHospital of HebeiMedical University and Hebei Cancer Institute, 169 Tianshan Road, 050035 Shijiazhuang, China.
推荐引用方式(GB/T 7714)：
Duan Yuqing,Jia Yunlong,Wang Tingting,et al.Potent therapeutic target of inflammation, virus and tumor: focus on interleukin-27[J].INTERNATIONAL IMMUNOPHARMACOLOGY.2015,26(1):139-146.doi:10.1016/j.intimp.2015.03.016.
APA：
Duan, Yuqing,Jia, Yunlong,Wang, Tingting,Wang, Yu,Han, Xiaonan&Liu, Lihua.(2015).Potent therapeutic target of inflammation, virus and tumor: focus on interleukin-27.INTERNATIONAL IMMUNOPHARMACOLOGY,26,(1)
MLA：
Duan, Yuqing,et al."Potent therapeutic target of inflammation, virus and tumor: focus on interleukin-27".INTERNATIONAL IMMUNOPHARMACOLOGY 26..1(2015):139-146
