Relationship between expression of P27, Fragile Histidine Triad (FHT), phosphatase and tensin homolog deleted on chromosome ten (PTEN), P73, and prognosis in esophageal squamous cell carcinoma
机构：[1]Department of Pathology, Institute of the Fourth Hospital of Hebei Medical University, No. 12, Jiankangt Road, Shijiazhuang, 050011, PR China医技科室病理科河北医科大学第四医院[2]Department of Surgery, Institute of the Fourth Hospital of Hebei Medical University, No. 12, Jiankangt Road, Shijiazhuang, 050011, PR China河北医科大学第四医院
To investigate the significance between the expression of P27, Fragile Histidine Triad (FHIT), phosphatase and tensin homolog deleted on chromosome ten (PTEN), and P73 in esophageal squamous cell carcinoma (ESCC), paraffin-embedded tissue blocks of 200 cases were obtained from the Fourth Hospital of Hebei Medical University. The sections were used for (HE) and immunohistochemical staining streptavidin-perosidase (SP). The immunologic reagents used included antibodies against P27, FHIT, PTEN, and P73. From I- to II- and III-graded ESCC, the positive expression of P27 was decreased, but the P73 was increased, showing a ladded change (P <.05). The oncogene and tumor suppressor gene protein expression were related to the differentiation and can be one of the factors of influencing prognosis. The oncogene and tumor suppressor gene protein expression was related to the prognostic factor, and thus, it is valuable for clinical treatment and judging prognosis to detect the expression of P27, FHIT, PTEN, and P73 in ESCC. (C) 2014 Elsevier Inc. All rights reserved.
第一作者机构：[1]Department of Pathology, Institute of the Fourth Hospital of Hebei Medical University, No. 12, Jiankangt Road, Shijiazhuang, 050011, PR China
通讯作者：
通讯机构：[1]Department of Pathology, Institute of the Fourth Hospital of Hebei Medical University, No. 12, Jiankangt Road, Shijiazhuang, 050011, PR China[2]Department of Surgery, Institute of the Fourth Hospital of Hebei Medical University, No. 12, Jiankangt Road, Shijiazhuang, 050011, PR China
推荐引用方式(GB/T 7714)：
Chen Yanning,Wang Xiaoling,Li Fang,et al.Relationship between expression of P27, Fragile Histidine Triad (FHT), phosphatase and tensin homolog deleted on chromosome ten (PTEN), P73, and prognosis in esophageal squamous cell carcinoma[J].ANNALS OF DIAGNOSTIC PATHOLOGY.2015,19(1):33-36.doi:10.1016/j.anndiagpath.2014.12.004.
APA：
Chen, Yanning,Wang, Xiaoling,Li, Fang,Zhang, Jingling,Ma, Li&Liu, Yueping.(2015).Relationship between expression of P27, Fragile Histidine Triad (FHT), phosphatase and tensin homolog deleted on chromosome ten (PTEN), P73, and prognosis in esophageal squamous cell carcinoma.ANNALS OF DIAGNOSTIC PATHOLOGY,19,(1)
MLA：
Chen, Yanning,et al."Relationship between expression of P27, Fragile Histidine Triad (FHT), phosphatase and tensin homolog deleted on chromosome ten (PTEN), P73, and prognosis in esophageal squamous cell carcinoma".ANNALS OF DIAGNOSTIC PATHOLOGY 19..1(2015):33-36
