Insulin-like growth factor binding protein-3 (IGFBP-3) exerts anti-proliferative or pro-apoptotic effects through IGF-dependent as well as IGF-independent mechanisms in vitro. The purpose of this study was to examine the association between genetic variants in IGFBP-3 (rs2270628) and the risk of esophageal squamous cell carcinoma (ESCC) in a Chinese Han population. Five hundred ESCC cases and 500 cancer-free controls of the Chinese Han population were involved in this study. The IGFBP-3 single-nucleotide polymorphism (SNP) rs2270628 was genotyped and the estimated adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for its association with the risk of ESCC were determined using unconditional logistic regression analysis. Compared with the rs2270628 CC genotype, TT genotype was associated with a significantly increased ESCC risk with OR (95% CI) of 2.07 (1.05-4.09), but CT genotype was not (OR = 1.25, 95% CI = 0.94-1.66). IGFBP-3 SNP rs2270628 may contribute to the risk of ESCC in the Chinese Han population.
第一作者机构：[1]Hebei Med Univ, Dept Thorac Surg, Hosp 4, Shijiazhuang, Hebei Province, Peoples R China
通讯作者：
通讯机构：[1]Hebei Med Univ, Dept Thorac Surg, Hosp 4, Shijiazhuang, Hebei Province, Peoples R China
推荐引用方式(GB/T 7714)：
Yang H. -P.,Liu J. -F.,Rao J.,et al.Insulin-like growth factor binding protein-3 (IGFBP-3) genetic variant and the risk of esophageal squamous cell carcinoma in a Chinese population[J].GENETICS AND MOLECULAR RESEARCH.2014,13(2):4146-4153.doi:10.4238/2014.May.30.10.
APA：
Yang, H. -P.,Liu, J. -F.,Rao, J.,Zhang, X. -M.,Qian, H. -L....&Zhao, Z. -L..(2014).Insulin-like growth factor binding protein-3 (IGFBP-3) genetic variant and the risk of esophageal squamous cell carcinoma in a Chinese population.GENETICS AND MOLECULAR RESEARCH,13,(2)
MLA：
Yang, H. -P.,et al."Insulin-like growth factor binding protein-3 (IGFBP-3) genetic variant and the risk of esophageal squamous cell carcinoma in a Chinese population".GENETICS AND MOLECULAR RESEARCH 13..2(2014):4146-4153
