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Expression of lysophosphatidic acid receptors in the human lower esophageal sphincter

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收录情况： ◇ SCIE

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机构： [1]Department of Thoracic Surgery, Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China

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关键词： sling fibers human lysophosphatidic acid receptors lower esophageal sphincter clasp fibers

摘要：

Lysophosphatidic acid (LPA) is a bioactive lipid that is involved in a variety of physiological and pathological processes occurring in the gastrointestinal tract. It acts via six distinct types of receptors, LPA1, LPA2, LPA3, LPA4, LPA5 and LPA6, which belong to the family of G protein-coupled receptors. The aim of the present study was to detect the expression of the LPA receptors in the human lower esophageal sphincter (LES). Quantitative polymerase chain reaction and western blotting were used to analyze the expression of LPA1-6 receptors in sling and clasp fibers from the human LES. The results showed that the protein and mRNA expression levels of various LPA receptors were significantly different. Specifically, the mRNA and protein expression levels of the LPA1 receptor were higher compared with those of the other receptors. The prevalence of the LPA1 receptor mRNA and protein indicates that the LPA1 receptor is likely to be involved in the regulation of human LES functions.

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出版当年[2014]版：

大类 | 4 区医学

小类 | 4 区医学：研究与实验

最新[2025]版：

大类 | 4 区医学

小类 | 4 区医学：研究与实验

JCR分区：

出版当年[2014]版：

Q4 MEDICINE, RESEARCH & EXPERIMENTAL

最新[2023]版：

Q3 MEDICINE, RESEARCH & EXPERIMENTAL

影响因子： 2.4 最新[2023版] 2.3 最新五年平均 1.269 出版当年[2014版] 1.237 出版当年五年平均 0.941 出版前一年[2013版] 1.28 出版后一年[2015版]

第一作者：

第一作者机构： [1]Department of Thoracic Surgery, Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China

通讯作者：

通讯机构： [1]Department of Thoracic Surgery, Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China [*1]Department of Thoracic Surgery, Fourth Hospital, Hebei Medical University, 12 Jiankang Road, Shijiazhuang, Hebei 050011, P.R. China

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