机构：[1]Department of Orthopedics, The Fourth Affiliated Hospital of Hebei Medical University, 12 Health Road, Shijiazhuang 050011, China河北医科大学第四医院[2]Department of General Surgery, The Fourth Affiliated Hospital of Hebei Medical University, 12 Health Road, Shijiazhuang 050011, China河北医科大学第四医院[3]Beijing Key Laboratory of Drug Target and Screening Research, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China[4]Department of Cardiology, The Fourth Hospital of Hebei Medical University, 12 Health Road, Shijiazhuang 050011, China临床科室心血管内科河北医科大学第四医院
Leptin (from the Greek word "lepto'' meaning "thin") is a 167-amino acid peptide hormone encoded by the obesity (ob) gene and secreted by white adipocytes. Blood leptin concentrations are increased in obese individuals. Leptin is a satiety hormone that provides negative feedback to the hypothalamus, controlling appetite and energy expenditure. Leptin binds to presynaptic GABAergic neurons to produce its effect, raising the distinct possibility that GABAergic axon terminals are the ultimate subcellular site of action for its effects. Released into the circulation, leptin crosses the blood-brain barrier and binds to leptin receptors, influencing the activity of various hypothalamic neurons, as well as encoding orexigenic and anorexigenic neuropeptides. Moreover, leptin affects a wide range of metabolic functions in the peripheral tissue. In this review, we discuss some physiologic functions of leptin, including effects on obesity and some effects of leptin replacement therapy.
基金：
Department of Science and Technology of Hebei Province [11276156]; Key medical scientific research planned of health Department of Hebei Province [20120357]
第一作者机构：[1]Department of Orthopedics, The Fourth Affiliated Hospital of Hebei Medical University, 12 Health Road, Shijiazhuang 050011, China
共同第一作者：
通讯作者：
通讯机构：[4]Department of Cardiology, The Fourth Hospital of Hebei Medical University, 12 Health Road, Shijiazhuang 050011, China
推荐引用方式(GB/T 7714)：
Feng Helin,Zheng Lihua,Feng Zhangying,et al.The role of leptin in obesity and the potential for leptin replacement therapy[J].ENDOCRINE.2013,44(1):33-39.doi:10.1007/s12020-012-9865-y.
APA：
Feng, Helin,Zheng, Lihua,Feng, Zhangying,Zhao, Yaheng&Zhang, Ning.(2013).The role of leptin in obesity and the potential for leptin replacement therapy.ENDOCRINE,44,(1)
MLA：
Feng, Helin,et al."The role of leptin in obesity and the potential for leptin replacement therapy".ENDOCRINE 44..1(2013):33-39
