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Decreased Expression and Aberrant Methylation of Raf Kinase Inhibitory Protein Gene in Esophageal Squamous Cell Carcinoma

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收录情况： ◇ SCIE

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机构： [1]Tumor Treatment Department, The Bethune International Peace Hospital, Shijiazhuang, Hebei, China, [2]Laboratory of Pathology, Hebei Cancer Institute, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China

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关键词： RKIP Esophageal squamous cell carcinoma Expression Methylation

摘要：

Raf kinase inhibitory protein (RKIP) gene is considered to be a suppressor of metastasis involved in various carcinomas. In the present study, we observed that promoter methylation repressed the expression of RKIP in TE-13 cell line. 5-Aza treatment and stable transfection of RKIP resulted in a significant inhibition of TE-13 cell proliferation. The promoter hypermethylation of RKIP was found to occur in dysplastic tissues and a close correlation was noted between RKIP methylation and the loss of mRNA and protein expression of the gene in ESCC specimens. In summary, RKIP may act as a tumor suppressor gene in esophageal cancer.

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出版当年[2012]版：

大类 | 4 区医学

小类 | 4 区肿瘤学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区肿瘤学

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出版当年[2012]版：

Q3 ONCOLOGY

最新[2023]版：

Q3 ONCOLOGY

影响因子： 1.8 最新[2023版] 2.1 最新五年平均 2.238 出版当年[2012版] 2.269 出版当年五年平均 1.847 出版前一年[2011版] 2.06 出版后一年[2013版]

第一作者：

第一作者机构： [1]Tumor Treatment Department, The Bethune International Peace Hospital, Shijiazhuang, Hebei, China,

通讯作者：

通讯机构： [1]Tumor Treatment Department, The Bethune International Peace Hospital, Shijiazhuang, Hebei, China, [*1]Tumor Treatment Department, Bethune International Peace Hospital, Zhongshanlu 398, Shijiazhuang 050082, Hebei, China.

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