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Aberrant methylation of the CpG island of HLTF gene in gastric cardia adenocarcinoma and dysplasia

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收录情况： ◇ SCIE

作者：
Guo, Wei[1] * ; Dong, Zhiming[1,*1] ; Guo, Yanli[1] ; Chen, Zhifeng[1] ; Kuang, Gang[1] ; Yang, Zhibin[1] ;
机构： [1]Department of Pathology, Hebei Cancer Institute, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China
出处：
DOI： 10.1016/j.clinbiochem.2011.04.006
ISSN：

关键词： HLTF Methylation Gastric cardia adenocarcinoma Dysplasia

摘要：
Objectives: To investigate the promoter methylation of HLTF in the tissues and plasma of patients with gastric cardia adenocarcinoma (GCA) and dysplasia. Design and methods: Nested MSP approach was used to detect HLTF methylation status. Results: The frequency of HLTF methylation in high grade dysplasia and GCA tumor tissues was significantly higher than that in chronic inflammation tissues and was significantly associated with upper gastrointestinal cancers (UGIC) family history and protein and mRNA expression of the gene. HLTF methylation was not found in the plasma of patients with chronic inflammation and low grade dysplasia, while 4.0% (1/25) of patients with high grade dysplasia and 20.8% of (20/96) GCA patients were detected with hypermethylation of HLTF in the plasma. Conclusions: In all, HLTF methylation may exist in gastric cardia dysplasia stages and may play important role in the development of GCA especially in individuals with UGIC family history. (C) 2011 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

基金：
considerable distinctive subjects foundation of Hebei province
语种：
外文
被引次数：
WOS：
PubmedID：
中科院分区：
出版当年[2011]版：
大类 | 4 区 医学
小类 | 3 区 医学实验技术
最新[2025]版：
大类 | 3 区 医学
小类 | 3 区 医学实验技术
JCR分区：
出版当年[2011]版：
Q2 MEDICAL LABORATORY TECHNOLOGY
最新[2023]版：
Q2 MEDICAL LABORATORY TECHNOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2011版] 出版当年五年平均 出版前一年[2010版] 出版后一年[2012版]

第一作者：
第一作者机构： [1]Department of Pathology, Hebei Cancer Institute, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China
通讯机构： [*1]Hebei Cancer Institute, the fourth hospital of Hebei Medical University, Jiankanglu 12, Shijiazhuang 050011, Hebei, China
推荐引用方式(GB/T 7714)：
Guo Wei,Dong Zhiming,Guo Yanli,et al.Aberrant methylation of the CpG island of HLTF gene in gastric cardia adenocarcinoma and dysplasia[J].CLINICAL BIOCHEMISTRY.2011,44(10-11):784-788.doi:10.1016/j.clinbiochem.2011.04.006.
APA：
Guo, Wei,Dong, Zhiming,Guo, Yanli,Chen, Zhifeng,Kuang, Gang&Yang, Zhibin.(2011).Aberrant methylation of the CpG island of HLTF gene in gastric cardia adenocarcinoma and dysplasia.CLINICAL BIOCHEMISTRY,44,(10-11)
MLA：
Guo, Wei,et al."Aberrant methylation of the CpG island of HLTF gene in gastric cardia adenocarcinoma and dysplasia".CLINICAL BIOCHEMISTRY 44..10-11(2011):784-788

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