机构：[1]Department of Molecular Biology, Hebei Cancer Institute, Hebei Medical University, Fourth Hospital, Jiankanglu 12, Shijiazhuang 050011, China临床科室医技科室河北省肿瘤研究所分子生物学室河北医科大学第四医院[2]Department of Obstetrics and Gynaecology, Hebei Medical University, Fourth Hospital, Shijiazhuang, China临床科室妇科河北医科大学第四医院
Backgrounds and aims. E-cadherin plays an important role in the origin of epithelial ovarian cancer. However, the exact molecular mechanism by which this occurs is unknown. The polymorphisms located at the E-cadherin may contribute to an increased risk for certain cancers. In this paper, we studied the association between polymorphisms of E-cadherin and the risk of epithelial ovarian cancer. Methods. We assessed the -160C/A, -347G/GA polymorphism within the promoter region and 3'-UTR+54C/T polymorphism of E-cadherin in epithelial ovarian cancer and control women. We also tested the expression of E-cadherin protein in ovarian cancer tissue among three genotype (3'UTR+54C/T polymorphism) carriers. Results. There was no significant difference in genotype distribution of the -160C/A and -347G/GA SNPs in the E-cadherin gene promoter region between ovarian cancer patients and controls, but haplotype -160A/-347GA relative to haplotype -160C/-347G was 48.6 (95% CI=2.9-806.2) for epithelial ovarian cancer risk. The C/C genotype of the 3'-UTR +54C/T polymorphism relative to the C/T+T/T genotype was 1.85 (95% CI=1.27-2.69) for epithelial ovarian cancer risk. E-cadherin protein expression in was lower in C/C genotype carriers than T allele carriers in ovarian cancer tissue (P=0.02). Conclusions. The C/C genotype of 3'-UTR C/T SNP and -160C/-374GA haplotype in E-cadherin gene may be a potential susceptibility factor for risk of epithelial ovarian cancer in Chinese, which indicated that the lower expression of E-cadherin might play an important role in the pathogenesis of epithelial ovarian cancer. (C) 2007 Elsevier Inc. All rights reserved.
第一作者机构：[1]Department of Molecular Biology, Hebei Cancer Institute, Hebei Medical University, Fourth Hospital, Jiankanglu 12, Shijiazhuang 050011, China
通讯作者：
通讯机构：[1]Department of Molecular Biology, Hebei Cancer Institute, Hebei Medical University, Fourth Hospital, Jiankanglu 12, Shijiazhuang 050011, China
推荐引用方式(GB/T 7714)：
Li Yan,Liang Jun,Kang Shan,et al.E-cadherin gene polymorphisms and haplotype associated with the occurrence of epithelial ovarian cancer in Chinese[J].GYNECOLOGIC ONCOLOGY.2008,108(2):409-414.doi:10.1016/j.ygyno.2007.10.024.
APA：
Li, Yan,Liang, Jun,Kang, Shan,Dong, Zhiming,Wang, Na...&Zhao, Xiwa.(2008).E-cadherin gene polymorphisms and haplotype associated with the occurrence of epithelial ovarian cancer in Chinese.GYNECOLOGIC ONCOLOGY,108,(2)
MLA：
Li, Yan,et al."E-cadherin gene polymorphisms and haplotype associated with the occurrence of epithelial ovarian cancer in Chinese".GYNECOLOGIC ONCOLOGY 108..2(2008):409-414
医学